Effects of Guanxin Tongmai Capsule on Cytokinesrelated to Atherosclerosis in Patients with Coronary Heart Disease
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Effects of Guanxin Tongmai Capsule on Cytokinesrelated to Atherosclerosis in Patients with Coronary Heart Disease
Chinese Journal of Experimental Traditional Medical FormulaeVol. 18, Issue 1, Pages: 210-212(2012)
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Published:2012
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LEI Jian, WU Yong-hong, CHEN Lie, et al. Effects of Guanxin Tongmai Capsule on Cytokinesrelated to Atherosclerosis in Patients with Coronary Heart Disease[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(1): 210-212.
DOI:
LEI Jian, WU Yong-hong, CHEN Lie, et al. Effects of Guanxin Tongmai Capsule on Cytokinesrelated to Atherosclerosis in Patients with Coronary Heart Disease[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(1): 210-212.DOI:
Effects of Guanxin Tongmai Capsule on Cytokinesrelated to Atherosclerosis in Patients with Coronary Heart Disease
Objective: To observe the levels of Guanxin Tongmai capsule on interleukin 6(IL-6)
tumor kecrosis fator-α(TNF-α)
endothelial cells micro particles(EMPs) and von willebrand factor(vWF) in patients with coronary heart disease and the action mechanism of Guanxin Tongmai capsule. Method :Sixty patients were divided randomly into treatment group(Guanxin Tongmai capsule 3# Tid) and control group(Tongxinluo capsule 3# Tid). After 4 weeks treatment
the results of IL-6
TNF-α
EMPs and vWF and the clinical effects were compared between the two groups. Result :There were no significant difference between the treatment group(85.7%)and the control group(90.0%) on ECG
no significant difference between the treatment group(92.9%)and the control group(93.3%) on clinical effect. The content of IL-6
TNF-α
EMPs and vWF in the two groups were both significantly decreased after treatment
no statistically significant difference between the two groups. Conclusion :Guanxin Tongmai capsule could decrease the content of IL-6
TNF-α
EMPs and vWF in the patients with coronary heart disease. Guanxin Tongmai capsule can play a considerable role compared with Tongxinluo capsule
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Related Institution
School of Clinical Medicine,Beijing University of Chinese Medicine
Beijing Key Laboratory of Chinese Materia Pharmacology,National Clinical Research Center of Traditional Chinese Medicine for Cardiovascular Diseases,Institute of Basic Medical Sciences, Xiyuan Hospital,China Academy of Chinese Medical Sciences
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