Objective :To observe the effect of sanhuatang on neurological function

brain edema and brain morphology of cerebral ischemia-reperfusion in rat. Method :The rats were randomly divided in sham operation group

model group

low dose group of sanhuatang

large dose group of sanhuatang and nimodipine group every group were medicated once each day and lasted for 7 days. The cerebral ischemia reperfusion model was established by blocking middle cerebral artery of rat with suture method prepare. The score of nervous symptoms in rats was made by Zealonga 5 class. The brain water content was calculated through weighing anhydrous brain and hydrous brain. The pathological changes of brain tissue was analyzed by HE staining. Result: In model group the neurological symptoms were severer than in the sham group(P<0.01)

brain water content was significantly higher(P<0.01)

swelling

denaturation

necrosis

inflammatory cell infiltration and vasodilator od never cells were observed. In large dose group neurological symptoms of rats was significantly relieved (P<0.05)

brain water content were significantly reduced (P<0.01). Conclusion : Sanhua decocotiom can protect injure of cerebral ischemia reperfusion in rats.