Objective: To establish a HPLC method for the determination of the dissolution rate of chlorphenamine maleate in Keteling capsules. Method: The dissolution rate was determined by HPLC

with 0.1 mol ·L-1 hydrochloric acid as dissolution medium and rotation speed at 100 r ·min-1

and the detection wavelength was as 264 nm. Result: The good linear relationship and the average recovery rate for chlorphenamine maleate were in the range of 0.012-0.072 μg (r=0.999 8)and 98.05％

RSD 2.34％(n=5). Conclusion: The method is simple

accurate and reproducible

and it can be used for the determination of the dissolution rate of chlorphenamine maleate in Keteling capsules.