Objective : To research the effect of Basil capsule on expression of osteopontin(OPN) and inducible nitric oxide synthase(iNOS) for transplanted liver cancer in rat after transcatheter arterial chemoembolization(TACE)

and to discussion the effect of basil capsule on hypoxia environmental. Method :Ten days after transplanted rat liver cancer model established

the successful rats model were randomly divided into five groups:without TACE group(A);TACE+ Saline group(B); TACE+ high-dose Basil capsule group(C); TACE+middose Basil capsule group(D); TACE+ low-dose Basil capsule group(E). For B to simulate the heal of TACE and give normal saline 10 mL·kg-1·d-1.For C

D and E to carry out Basil capsules 300

150

75 mg·kg-1·d-1ig

A of rats only for abdominal operations

without TACE.Ten days after embolism

the rats were sacrificed and the tumors were taken out and treated with chemoembolization. To demonstrate the expression rate of OPN and iNOS. Result : The expression rate of OPN and iNOS on B were higher than A(P<0.01).The expression rate of OPN and iNOS on C and D were lower than B(P<0.01).The expression rate of OPN and iNOS between D and E were higher than C (P<0.01). Conclusion : Basil capsule can obviously improve hypoxia environmental in local of rat hepatoma and can depress the expression of OPN and iNOS

can inhibit rat liver transplant tumor recurrence after TACE.