Pharmacokinetics and Tissue Distribution of Silybin Gelatin Microspheres  in Rats

CHEN Yong-shun; WU Zhen

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Pharmacokinetics and Tissue Distribution of Silybin Gelatin Microspheres in Rats

更新时间：2024-01-04

- Pharmacokinetics and Tissue Distribution of Silybin Gelatin Microspheres in Rats
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 18, Issue 2, Pages: 128-131(2012)
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- Published：2012
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CHEN Yong-shun, WU Zhen. Pharmacokinetics and Tissue Distribution of Silybin Gelatin Microspheres in Rats[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(2): 128-131.
DOI：

CHEN Yong-shun, WU Zhen. Pharmacokinetics and Tissue Distribution of Silybin Gelatin Microspheres in Rats[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(2): 128-131. DOI：

摘要

目的: 研究水飞蓟宾明胶微球在大鼠体内的药动学及组织分布。方法: 以水飞蓟宾注射液为参比

用3P 97软件计算药动学模型及药动学参数

用靶向效率来评价其在大鼠体内的组织分布及靶向性。结果: 水飞蓟宾明胶微球在大鼠体内的药动学模型符合二室模型

主要药动学参数为: t 1/2α=(0.572 8±0.108 6) h

t 1/2β=(20.686 6±1.058 8) h

CL=(0.003 8± 0.001 4) mL·h·Kg-1

AUC0→∞=(211.095 0±10.272 8) mg·h·L-1

其在肝脏、脾脏、心脏及肾脏的靶向效率分别为2.093

1.986

0.634

0.259。结论: 与水飞蓟宾注射液相比

水飞蓟宾明胶微球能提高对肝脏

脾脏的趋向性

有利于提高其治疗作用。

Abstract

Objective: To investigate in vivo pharmacokinetics and tissue distribution of silybin gelatin microspheres in rats. Method: With silybin injection as reference

pharmacokinetic model and parameters were calculated by 3P97. In vivo tissue distribution and targeting of silybin gelatin microspheres in rats were evaluated by targeting efficiency. Result: Pharmacokinetic data fitted a two-compartment model

main pharmacokinetic parameters of silybin gelatin microspheres were as follows: t 1/2α=(0.572 8±0.108 6) h

t 1/2β=(20.686 6±1.058 8) h

CL=(0.003 8±0.001 4) mL·h·kg-1

AUC0→∞=(211.095 0±10.272 8) mg·h·L-1.Targeting efficiency of it in liver

spleen

heart and kidney were 2.093

1.986

0.634

0.259. Conclusion: Compared to silybin injection

silybin gelatin microspheres could improve tendency for liver and spleen

and help improving its therapeutic effect.

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DAI Guoliang

HANG Huaxi

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WANG Yiran

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Related Institution

Affiliated Hospital of Nanjing University of Chinese Medicine

Affiliated Taihe Hospital of Hubei University of Medicine

School of Life Sciences，Beijing University of Chinese Medicine

Third Grade Laboratory of Traditional Chinese Medicine（TCM） Preparations，National Administration of TCM，Shuguang Hospital Affiliated to Shanghai University of TCM

Sichuan Academy of Chinese Medicine Sciences

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