Quality Control and  Transdermal Effects of Testosterone Undecanoate Microemulsion Cataplasm

ZHANG Xiao-wei; YANG Dan; LIU Dan-hua; HU Dong-mei; MENG Shu

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Quality Control and Transdermal Effects of Testosterone Undecanoate Microemulsion Cataplasm

更新时间：2024-01-04

- Quality Control and Transdermal Effects of Testosterone Undecanoate Microemulsion Cataplasm
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 18, Issue 2, Pages: 22-24(2012)
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- Published：2012
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ZHANG Xiao-wei, YANG Dan, LIU Dan-hua, et al. Quality Control and Transdermal Effects of Testosterone Undecanoate Microemulsion Cataplasm[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(2): 22-24.
DOI：

ZHANG Xiao-wei, YANG Dan, LIU Dan-hua, et al. Quality Control and Transdermal Effects of Testosterone Undecanoate Microemulsion Cataplasm[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(2): 22-24. DOI：

摘要

目的: 制备十一酸睾酮微乳

并以水溶性高分子材料为辅料制备外用微乳巴布剂。方法: 选用肉豆蔻酸异丙酯(IPM)为油相

Cremophor EL为表面活性剂

Larbrasol为辅助表面活性剂

制备微乳。使用聚乙烯吡咯烷酮(K-90)、聚丙烯酸钠(NP-700)等为基质

制备巴布剂。对制备的巴布剂进行了质量考察

采用体外扩散池法测定了巴布剂中十一酸睾酮的透皮渗透率。结果: 最终制备得到的微乳巴布剂中十一酸睾酮载药量400 μg·cm-2

经皮渗透速率3.822 μg·cm-2·h-1。结论: 所选择的微乳处方黏度小、粒径细腻、质量稳定

制备得到的巴布剂具有良好的涂展性、保湿性

且黏着力适中。微乳巴布剂具有明显的控释效果。

Abstract

Objective: To prepare testosterone undecanoate (TU) microemulsion

and microemulsion cataplasm was prepared with water-soluble polymer materials as accessories. Method: Isopropyl myristate was chosen for oil phase

Cremophor EL was selected as surfactants

Larbrasol was used as auxiliary surfactants to prepare microemulsion.PVP K-90 and NP-700 were used as matrix to prepare cataplasm.Quality of prepared cataplasm was investigated

transdermal penetration of TU was determined by in vitro diffusion cell method. Result: TU loading ability of prepared microemulsion cataplasm was 400 μg·cm-2.Percutaneous penetration of TU was 3.822 μg·cm-2·h-1. Conclusion: This selected microemulsion prescription had low viscosity

fine particle and stable quality.TU microemulsion cataplasma had good extension

moisture

viscosity

and obviously drug control-release ability.

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Related Institution

Tianjin University of Traditional Chinese Medicine

Institute of Chinese Materia Medica，China Academy of Chinese Medical Sciences

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Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences

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