Research on HPLC-DAD Fingerprint of Compound Tangmaikang

ZHAO Qi-peng; ZHANG Yi

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Research on HPLC-DAD Fingerprint of Compound Tangmaikang

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- Research on HPLC-DAD Fingerprint of Compound Tangmaikang
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 17, Issue 19, Pages: 101-104(2011)
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- Published：2011
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ZHAO Qi-peng, ZHANG Yi. Research on HPLC-DAD Fingerprint of Compound Tangmaikang[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(19): 101-104.
DOI：

ZHAO Qi-peng, ZHANG Yi. Research on HPLC-DAD Fingerprint of Compound Tangmaikang[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(19): 101-104. DOI：

摘要

目的: 建立糖脉康颗粒的HPLC-DAD指纹图谱

为评价及控制药品质量提供可靠方法。方法: 采用梯度洗脱方法对样品进行分析。DIKMA色谱柱(4.6 mm×250 mm

5 μm)

流动相0.4%冰乙酸-乙腈梯度洗脱

检测波长270 nm

柱温30 ℃;采用指纹图谱相似度软件进行数据分析。结果: 建立了糖脉康颗粒的HPLC-DAD对照指纹图谱

方法精密度、稳定性和重复性良好。标示了21个共有色谱峰

14批样品的色谱指纹图谱的相似度>0.80。结论: 糖脉康颗粒HPLC-DAD指纹图谱的建立

可为有效控制糖脉康颗粒成品制剂的质量提供参考。

Abstract

Objective: To establish a sensitive HPLC-DAD fingerprint method for controlling the quality of compound Tangmaikang. Method: HPLC analysis was performed on a Dikma C18 column(4.6 mm×250 mm

5 μm)

with a mixture of acetonitrile and water as mobile phase in gradient mode. The wavelength was set at 270 nm

and column temperature was 30 ℃. The data were processed by fingerprint similarity evaluation software. Result: A standard HPLC-DAD fingerprint for Compound Tangmaikang with 21 common peaks was established. The similarity of 14 batches of compound Tangmaikang was more than 0.80.Good precision

stability and repetition were showed. Conclusion: This method can be used for the quality control of compound Tangmaikang.

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Related Institution

Institute of Chinese Materia Medica，China Academy of Chinese Medical Sciences

State Key Laboratory of Southwestern Traditional Chinese Medicine（TCM） Resources， School of Pharmacy，Chengdu University of TCM

Sichuan Neo-green Pharmaceutical Technology Development Co. Ltd.，Pengzhou

Tianjin University of Traditional Chinese Medicine

Modern Research Center for Traditional Chinese Medicine，Shanxi University

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