JAK-STAT Cell Signaling Pathways Adjusting by Gualou Xiebai Banxia Decoction Preconditioning in Myocardial Ischemia Reperfusion Injury
|更新时间:2024-01-04
|
JAK-STAT Cell Signaling Pathways Adjusting by Gualou Xiebai Banxia Decoction Preconditioning in Myocardial Ischemia Reperfusion Injury
Chinese Journal of Experimental Traditional Medical FormulaeVol. 17, Issue 24, Pages: 147-150(2011)
作者机构:
作者简介:
基金信息:
DOI:
CLC:
Published:2011
稿件说明:
移动端阅览
DUAN Xue-tao, JIN Hong-bin, YI Ya-qiao, et al. JAK-STAT Cell Signaling Pathways Adjusting by Gualou Xiebai Banxia Decoction Preconditioning in Myocardial Ischemia Reperfusion Injury[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(24): 147-150.
DOI:
DUAN Xue-tao, JIN Hong-bin, YI Ya-qiao, et al. JAK-STAT Cell Signaling Pathways Adjusting by Gualou Xiebai Banxia Decoction Preconditioning in Myocardial Ischemia Reperfusion Injury[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(24): 147-150.DOI:
JAK-STAT Cell Signaling Pathways Adjusting by Gualou Xiebai Banxia Decoction Preconditioning in Myocardial Ischemia Reperfusion Injury
Objective : To explore JAK-STAT cell signaling pathways adjusting by Gualou Xiebai Banxia decoction precinditioning in myocardial ischemia reperfusion injury. Method :Sixty male SD rats were randomly divided into blank control (A) group
ischemia /reperfusion (B) group (I/R)
ischemia preconditioning (C) group (IPC)
GXBD pretreatment (D) group
AG490 processing (E) groups
there were 8 rats in each group. Ligation of the left anterior descending coronary artery for 30 minutes and 90 minutes reperfusion was performed
to make myocardial ischemia reperfusion injury
A
B
group were were given physiological saline
group D and E were treated with 4.95 g·kg-1 doses of GXBD and 2 mg·kg-1 dose of AG490.before 1 h of modelling. The serum adenosine (Ado) and gentle shock peptide (BK) level were measured
myocardial infarction area and JAK2
STAT3 protein expression of the myocardial tissue were detected. Result : The serum Ado and BK level in the model group and AG490 group were significantly decreased (P<0.05)
myocardial infarction area expanded significantly (P<0.01)
JAK2
STAT3 protein expression significantly reduced (P<0.05); GXBD group and the IPC group could make Ado
BK
JAK2
STAT3 level significantly increased (P<0.05)
myocardial infarction area reduced significantly (P<0.01). Conclusion: GXBD can raise the protein expressionof JAK2
STAT3
Adoand BK level and reduce myocardial infarction area to protect ischemia-reperfusion myocardial injury.
Mechanism of Taohong Siwutang Alleviating Myocardial Ischemia Reperfusion Injury in Ovariectomized Mice by Up-regulating Nrf2/HO-1 Signaling Pathway
Traditional Chinese Medicine in Treatment of Myocardial Ischemia-Reperfusion Injury by Regulating Adenosine 5'-monophosphate (AMP)-activated Protein Kinase: A Review
Establishment of Quality Control Method in Production of Jinshuibao Capsules
Determination of Adenosine in Weigan Effervescent Tablets by RP-HPLC
Related Author
YANG Yuming
ZHU Ying
LIU Changyi
CHENG Jing
HE Fei
HU Yaqi
LIU Jianhe
Xue-ting ZHANG
Related Institution
School of Nursing, Anhui University of Chinese Medicine
The Second Hospital of Anhui Medical University
Hunan University of Chinese Medicine
The First Hospital of Hunan University of Chinese Medicine
Key Laboratory of Identification and Safety Evaluation of Chinese Medicine, Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences