Objective: To study the effects of the ethanol extract from Ajuga decumbents on blood-activating and stasis-dissolving and anti-liver acute injury in mice. Method: Fifty mice were randomly divided into 5 groups:normal control group

aspirin group

ethanol extract from A.decumbents groups of low

middle and high doses. Treatments in according groups were given daily for 7 days. Glass capillary method and slide method were used to determinate the effects of the ethanol extraction of A. decumbens on blood-activating and stasis-dissolving by the clotting time in mice. Meanwhile we selected the intestinal mucosa to measure its nodal points of capillary network

the diameter of capillary and the blood’s flow velocity. Another 60 mice were randomly divided into 6 groups:normal control group

model group

bifendete group

ethanol extract from A. decumbents groups of low

middle and high doses. The acute liver injury model in mice was induced by CCl4 or D-GalN. Treatments in according groups were given daily for 7 days. The protective effect for liver was investigated by detecting the levels of ALT

AST in serum. Result: The ethanol extract from A. decumbens could significantly prolong the clotting time (P<0.05)

increase the blood flow velocity and the intestinal mucosa’s nodal points of capillary network (P<0.05) in normal mice. It could markedly decrease the level of ALT and AST in serum in the acute liver injured mice induced by CCl4 or D-GalN (P<0.05). Conclusion: The ethanol extract from A. decumbens has the effect of protecting liver. It may be related with effects of blood-activating and stasis-dissolving.