Preparation and Dissolution Investigation of Paeonol Self-Emulsifying Tablets

WEI Shi-jie; HUO Wu-zhen; CHEN Qing-tang

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Preparation and Dissolution Investigation of Paeonol Self-Emulsifying Tablets

更新时间：2024-01-04

- Preparation and Dissolution Investigation of Paeonol Self-Emulsifying Tablets
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 17, Issue 24, Pages: 29-31(2011)
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- Published：2011
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WEI Shi-jie, HUO Wu-zhen, CHEN Qing-tang. Preparation and Dissolution Investigation of Paeonol Self-Emulsifying Tablets[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(24): 29-31.
DOI：

WEI Shi-jie, HUO Wu-zhen, CHEN Qing-tang. Preparation and Dissolution Investigation of Paeonol Self-Emulsifying Tablets[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(24): 29-31. DOI：

摘要

目的 :研制丹皮酚高效快速的自乳化给药系统

提高起效时间和生物利用度。方法 :选择适宜油相、乳化剂、助乳化剂

并在此基础上绘制伪三元相图。通过对各处方比例的筛选

结合各处方载药量以及所形成微乳的稳定性

确定最佳处方并制备片剂

考察其乳化后微乳的粒径、形态和体外溶出情况。结果 :以油相为三辛酸/癸酸甘油酯

乳化剂为Cremophor EL

助乳化剂为丙二醇

丹皮酚在助乳化剂中的质量百分数为30%的处方为最佳处方;自乳化片在20 min之内溶出达到80%左右。结论 :所研制的自乳片具有粒径小、载药量高、性质稳定的优势

并能显著提高其体外溶出。

Abstract

Objective :To develop efficient and rapid of paeonol self-emulsifying drug delivery system

improve onset time and bioavailability. Method :Selected appropriate oil phase

emulsifier

cosurfactants

drew pseudoternary phase diagram on this basis.Determined optimum formulation and prepared tablets by screening proportion of formulations

combining drug loading of prescription and stability of microemulsion.Investigated size

shape and in vitro dissolution condition of emulsified microemulsion. Result :Optimum prescription was as follows:octyl decyl acid triglycerate

cremophor EL and propylene glycol were screened as oil phase

emulsifier and co-emulsifier respectively.The percentage of paeonol was 30% in co-emulsifier. Dissolution of self-emulsifying tablets reached 80% in 20 min. Conclusion :Advantages of developed self-emulsifying tablets were small size

high drug loading

stable

and could significantly improve in vitro dissolution.

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Related Institution

Geriatric Care and Health Laboratory，Anhui University of Chinese Medicine

School of Integrated Chinese and Western Medicine，Anhui University of Chinese Medicine

College of Pharmacy，Anhui University of Chinese Medicine

School of Pharmacy， Anhui University of Traditional Chinese Medicine

Key Laboratory of Research and Development of Traditional Chinese Medicine in Anhui Province， School of Pharmacy，Anhui University of Chinese Medicine

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