Study on Percutaneous Absorption of Panax notoginseng R, Ginsenoside Rg and Ginsenoside Rb through Guinea Pig’s Complete Skin

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Study on Percutaneous Absorption of Panax notoginseng R, Ginsenoside Rg and Ginsenoside Rb through Guinea Pig’s Complete Skin

更新时间：2024-01-04

- Study on Percutaneous Absorption of Panax notoginseng R, Ginsenoside Rg and Ginsenoside Rb through Guinea Pig’s Complete Skin
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 17, Issue 21, Pages: 130-134(2011)
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- Published：2011
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HE Bai-yin, XIE You-liang, LIU Chang-qing, et al. Study on Percutaneous Absorption of Panax notoginseng R, Ginsenoside Rg and Ginsenoside Rb through Guinea Pig’s Complete Skin [J]. Chinese journal of experimental traditional medical formulae, 2011, 17(21): 130-134.
DOI：

HE Bai-yin, XIE You-liang, LIU Chang-qing, et al. Study on Percutaneous Absorption of Panax notoginseng R, Ginsenoside Rg and Ginsenoside Rb through Guinea Pig’s Complete Skin [J]. Chinese journal of experimental traditional medical formulae, 2011, 17(21): 130-134. DOI：

摘要

目的: 研究三七提取液中三七皂苷R1

人参皂苷Rg1和人参皂苷Rb1等成分对完整豚鼠腹皮的透过性。方法: 采用Franz扩散池进行体外透皮实验

以完整豚鼠腹皮为渗透屏障

HPLC法测定三七皂苷R1

人参皂苷Rg1和人参皂苷Rb1的透过量。结果: 未加透皮促进剂时

三七提取液中三七皂苷R1

人参皂苷Rg1和人参皂苷Rb1等均不能透过完整豚鼠皮。在氮酮的促进下

三七提取液中的上述成分均可透过完整豚鼠腹皮

其透皮能力:人参皂苷Rg1>三七皂苷R1>人参皂苷Rb1;透皮促进剂氮酮加入量为2%时

上述成分的透皮作用较好。结论: 三七提取液中三七皂苷R1

人参皂苷Rg1和人参皂苷Rb1在2%氮酮促进下渗透效果较佳。

Abstract

Objective: To studying transdermal absorption patterns of notoginsenoside R1

ginsenoside Rg1 and ginsenoside Rb1 from extraction of Panax notoginseng in vitro. Method: Using Franz diffusion cell for in vitro transdermal experiments

complete guinea pigs’ abdomen skin was used as transdermal barrier; HPLC was applied to determent the amount of notoginsenoside R1

ginsenoside Rg1 and ginsenoside Rb1 which penetrated the test skin. Result: When no penetration enhancers like azone exsited

notoginsenoside R1

ginsenoside Rg1 and ginsenoside Rb1 couldnot pass through test skin at all. When 2% azone was add in the Panax notoginseng extraction

notoginsenoside R1

ginsenoside Rg1 and ginsenoside Rb1 could penetrate the test skin effectively. The sequence of its penetration capabilities was as follows: ginsenoside Rg1> notoginsenoside R1> ginsenoside Rb1. Conclusion: With the assisting of 2% Azone

notoginsenoside R1

ginsenoside Rg1 and ginsenoside Rb1 can effectively penetrate complete guinea pigs’ skin.

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