Preparation and  Release of Silybin Gelatin Microsphere

CHEN Yong-shun; CHEN Li

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Preparation and Release of Silybin Gelatin Microsphere

更新时间：2024-01-04

- Preparation and Release of Silybin Gelatin Microsphere
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 17, Issue 24, Pages: 23-26(2011)
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- Published：2011
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CHEN Yong-shun, CHEN Li. Preparation and Release of Silybin Gelatin Microsphere[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(24): 23-26.
DOI：

CHEN Yong-shun, CHEN Li. Preparation and Release of Silybin Gelatin Microsphere[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(24): 23-26. DOI：

摘要

目的 :制备水飞蓟宾明胶微球

并考察其体外释放性能。方法 :采用乳化交联法制备水飞蓟宾明胶微球。在单因素考察的基础上

利用正交设计优化水飞蓟宾明胶微球制备工艺

并对微球的粒径、形态、体外释放特性及初步稳定性进行研究。结果 :制得的微球形态圆整

平均粒径(1.45±0.27)μm

平均载药量(56.24±3.17)%

平均包封率(79.54±5.07)%

体外释放符合Higuchi方程

Q = 15.627 5t1/2-1.502 8 ( r = 0.998 5)

在室温下放置3个月质量稳定。结论 :实验制备的水飞蓟宾明胶微球初步稳定

其体外释放特性符合缓释制剂特征。

Abstract

Objective : To prepare silybin gelatin microsphere

and evaluate its in vitro release performance. Method : Silybin gelatin microsphere were prepared by emulsion chemical cross-linking method.Based on result of single-factor test

preparation technology was optimized by orthogonal test.And studies on particle size

shape

in vitro release characteristics and preliminary stability. Result : The microsphere were round and smooth.Average particle size was(1.45±0.27)μm

drug loading rate was(56.24±3.17)% and average entrapment was(79.54±5.07)%.Drug release in vitro profile could be described by Higuchi equation Q = 15.627 5t1/2-1.502 8 ( r = 0.998 5).The microsphere was stable at room temperature for 3 months. Conclusion :In this study

silybin gelatin microsphere was preliminary stable

its in vitro release characteristics conformed with characteristics of sustained-release formulations.

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