Effect of Kaixin Jieyu Decoction on Concentraions of Monoamine Neurotransmitters in Brain of the Depression Rats
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Effect of Kaixin Jieyu Decoction on Concentraions of Monoamine Neurotransmitters in Brain of the Depression Rats
Chinese Journal of Experimental Traditional Medical FormulaeVol. 17, Issue 17, Pages: 221-223(2011)
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Published:2011
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GUAN Tao, HUANG Xue-kuan, CHEN Di, et al. Effect of Kaixin Jieyu Decoction on Concentraions of Monoamine Neurotransmitters in Brain of the Depression Rats[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(17): 221-223.
DOI:
GUAN Tao, HUANG Xue-kuan, CHEN Di, et al. Effect of Kaixin Jieyu Decoction on Concentraions of Monoamine Neurotransmitters in Brain of the Depression Rats[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(17): 221-223.DOI:
Effect of Kaixin Jieyu Decoction on Concentraions of Monoamine Neurotransmitters in Brain of the Depression Rats
Objective: To investigate the effects of Kaixin Jieyu decoction on the concentraion changes of norepinephrine (NE)
dopamine(DA) and serotomin(5-HT) in brain of depression model in rats. Method: Thirty male SD rats were evenly randomized into normal
model and medical groups. Depression model of rat was produced by using chronic unpredictable mild stress stimulation (forced ice-water swimming
electric shock
tail-clamping
etc) combined with lonely raising for 21 days.At the same time of producing the depression model
Kaixin Jieyu decoction (40 g ·kg-1) was given to the medical group rats
once daily
continuously for 21 days.The concentraions of NE
DA and 5-HT were detected by HPLC-ECD. Result: The concentraions of NE
DA and 5-HT were reduced significantly in brain of the model rats compared to that of the normal group(P<0.05);also the concentraions of NE
DA and 5-HT were increased significantly in brain of Kaixin Jieyu decoction group compared to that of the model group (P<0.05). Conclusion: The mechanism for anti-depression of Kaixin Jieyu decoction may be correlative to regulating the balance of monamine transmitter.
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Related Institution
Affiliated Hospital of Nanjing University of Chinese Medicine
School of Basic Medicine, Gansu University of Chinese Medicine
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