The Protective Effects of Compatibility of Dioscin and Borneol on the Focal Cerebral Ischemia in Rats
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The Protective Effects of Compatibility of Dioscin and Borneol on the Focal Cerebral Ischemia in Rats
Chinese Journal of Experimental Traditional Medical FormulaeVol. 17, Issue 24, Pages: 151-153(2011)
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Published:2011
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ZHANG Xiao-shuang, ZHANG En-hu, SHEN Xin, et al. The Protective Effects of Compatibility of Dioscin and Borneol on the Focal Cerebral Ischemia in Rats[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(24): 151-153.
DOI:
ZHANG Xiao-shuang, ZHANG En-hu, SHEN Xin, et al. The Protective Effects of Compatibility of Dioscin and Borneol on the Focal Cerebral Ischemia in Rats[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(24): 151-153.DOI:
The Protective Effects of Compatibility of Dioscin and Borneol on the Focal Cerebral Ischemia in Rats
Objective :To investigate the protective effects of compatibility of dioscin and borneol on the focal cerebral ischemia in rats. Method :Rats were randomly divided into control group
model control group
groups with prescription 1-6 of compatibility of diosgenin and borneol
compatibility of diosgenin and borneol was based on the method of increase-decrease design method of experiment with baseline geometric proportion. Rats were given medicine of 10 mL·kg-1intragastrically
once a day
lasting 7 days
after 1 h of the last administration
focal cerebral ischemia model was established in rats of the middle cerebral artery
determining neurological behavior score after the rats were awake immediately
TTC staining was used to determine method infarction area and brain water content after 24 h of model . Result :Compared with model group
rescription 2
3 could alleviate neurological score
decrease infarct size
brain water content(P< 0.05
P< 0.01)
prescription 1 can reduce neurological score
infarct size and brain water content(P< 0.05)
prescription 4
5
6 have no significant differences. Conclusion :The best ratio of dioscin and borneol are 8 ∶2 and 6 ∶4 in terms of protection on focal cerebral ischemia in rats.
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Effect of Yinxing Mihuan Oral Solution on Neovascularization and Vascular Remodeling in Chemical Photothrombosis-induced Focal Cerebral Ischemia Mouse Model
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