Objective: To observe influence of Heart-Protection Musk Pill(HMP)on inflammatory factor in myocardial tissue in rats with acute myocardial infarction (AMI)

and to explore the mechanism of HMP for imroving ventricular remodeling. Method: Left anterior desecending coronary arteries of rats were ligated to make AMI model

seventy SD male rats were randomly divided into control group

sham operation group

AMI group

HMP 14 mg·kg-1·d-1 group

HMP 28 mg·kg-1·d-1 group and simvastatin group. Two weeks later

hemodynamic parameters were measured

and ELISA was used to determine IL-6

TNF-α in myocardial tissue. Result: Compared with control group

LVESP

LV+dp/dtmax and LV-dp/dtmax were markedly decreased(P<0.01)

while LVEDP markedly were increased(P<0.01)and content of IL-6 and TNF-α markedly increased(P<0.05 or P<0.01)in AMI group. Compared with those in AMI group

LVESP and LV±dp/dtmax markedly increased(P<0.05 or P<0.01)

while LVEDP and Content of IL-6

TNF-α markedly decreased(P<0.05 or P<0.01)in HMP group. Conclusion: HMP can improve hemodynamic parameters in model rats with AMI and reduce the release of inflammatory factor in myocardial tissue.This may be the mechanism of HMP for improving ventricular remodeling.