Objective: To study the influence of complex herba lysmachiae gramules on the experimental kidney stone and its diuretic

spasmolyti and anti-inflammatory effects. Method: Fifty Wistar rats (n=10) were randomly divided into five group

the normal goups

the model group

the Shenshitong gramules group(3.3 g ·kg-1)

high complex herba lysmachiae gramules group(7.4 g ·kg-1) and low complex herba lysmachiae gramules group(1.8 g ·kg-1). The rat model of renal calcium oxalate stones was induced by administrated ethylene glycol and ammonia chloride

after 8 weeks modeled and administered

the incidence of kedney stone

calaium in kedneys

serum BUN

serum Cr were detected. The effects of complex herba lysmachiae gramules on ureter smooth muscle of rabbits in vitro

water-loaded diuretic in rats and anti-inflammatory was evaluated. Result: The number of renal stone formation

the contentration of calcum in kedneys

serum BUN and serum Cr were lower in high complex herba lysmachiae gramules group than that in model group

and lasted diuretic effects in water-loaded rat. High complex herba lysmachiae gramules group could obviously inhibit the average tension amplified on the ureter smooth muscle induced by Ach

and could markedly suppressed xylene-caused mouse ear swelling and granuloma by cotton ball. Conclusion: Complex herba lysmachiae gramules could inhibit calcium oxalate stone formation in experimental rats

and had diuresis

spasmolytic effects in vitro and anti-inflammatory actions.