Anti-fatigue Effect and Mechanism of Atria1 Natriuretic Peptide on Gastrocnemius in Swimming-Induced Fatigue Mice

LI Da-yong; HONG Lan; YU Li; LI Hai-yan; LIU Li-ping

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Anti-fatigue Effect and Mechanism of Atria1 Natriuretic Peptide on Gastrocnemius in Swimming-Induced Fatigue Mice

更新时间：2024-01-04

- Anti-fatigue Effect and Mechanism of Atria1 Natriuretic Peptide on Gastrocnemius in Swimming-Induced Fatigue Mice
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 17, Issue 20, Pages: 221-223(2011)
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- Published：2011
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LI Da-yong, HONG Lan, YU Li, et al. Anti-fatigue Effect and Mechanism of Atria1 Natriuretic Peptide on Gastrocnemius in Swimming-Induced Fatigue Mice[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(20): 221-223.
DOI：

LI Da-yong, HONG Lan, YU Li, et al. Anti-fatigue Effect and Mechanism of Atria1 Natriuretic Peptide on Gastrocnemius in Swimming-Induced Fatigue Mice[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(20): 221-223. DOI：

摘要

目的: 观察和探讨心房钠尿肽(atria1 natriuretic peptide

ANP)对小鼠的抗疲劳作用及其机制。方法: 观察ANP 13.10

6.55 ng·kg-1 iv对小鼠负重游泳时间及对游泳力竭小鼠腓肠肌MDA含量的影响;离体试验观察ANP高质量浓度13.10 ng·kg-1对H2O2 (0.2mol·L-1)诱导小鼠腓肠肌MDA含量的影响。结果: ANP 13.10 ng·kg-1能够明显延长小鼠的游泳力竭时间(P<0.01);并能使小鼠腓肠肌MDA含量显著降低(P<0.05);ANP 13.10 μg·L-1对H2O2致小鼠腓肠肌组织损伤有保护作用(P<0.001)

而蛋白激酶G的阻断剂LY83583可阻止这种保护作用(P<0.01)。结论: ANP具有抗运动性疲劳的作用

其作用与ANP-环磷酸鸟苷-蛋白激酶G(ANP-cGMP-PKG)信号转导途径有关。

Abstract

Objective: To study the anti-fatigue effect and mechanism of atrial natriuretic peptide(ANP)on mice. Method: We observed the effect of ANP(13.10

6.55 ng·kg-1

iv) on the weight-loaded swimming time of the mice and the changes of gastrocnemius malonaldehyde (MDA). In vitro experiment

we observed the effect of high dose ANP(13.10 ng·kg-1) on H2O2(0.2 mol·L-1)induced mice gastrocnemius MDA. Result: ANP (13.10 ng·kg-1) could significant increase weight-loaded swimming time(P<0.01) and reduced the contents of MDA(P<0.05)compared with control group; ANP (13.10 μg·L-1) had the protective effect on H2O2 induced tissue injury of gastrocnemius (P<0.001)

but the blocker LY83583 of protein kinase G prevented the protective effect. Conclusion: ANP has the anti-fatigue effect

its role relevant to the signal transduction pathway of ANP-cGMP-protein kinase G(ANP-cGMP-PKG).

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