Transfer Rate of Chlorgenic Acid in Preparation Process of Yinqiao Jiedu Soft Capsules

LIU De-jun; ZHANG Yuan-yuan; ZHANG Ai-li; GOU Qiong-xin

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Transfer Rate of Chlorgenic Acid in Preparation Process of Yinqiao Jiedu Soft Capsules

更新时间：2024-01-04

- Transfer Rate of Chlorgenic Acid in Preparation Process of Yinqiao Jiedu Soft Capsules
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 17, Issue 21, Pages: 23-26(2011)
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- Published：2011
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LIU De-jun, ZHANG Yuan-yuan, ZHANG Ai-li, et al. Transfer Rate of Chlorgenic Acid in Preparation Process of Yinqiao Jiedu Soft Capsules[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(21): 23-26.
DOI：

LIU De-jun, ZHANG Yuan-yuan, ZHANG Ai-li, et al. Transfer Rate of Chlorgenic Acid in Preparation Process of Yinqiao Jiedu Soft Capsules[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(21): 23-26. DOI：

摘要

目的: 研究银翘解毒软胶囊制备过程中各环节绿原酸的转移率

为制备工艺优化及质量控制标准修订提供依据。方法: 按《中国药典》所载银翘解毒软胶囊的处方与工艺

用HPLC测定制备过程各环节绿原酸的转移率及相对于上一步的保留率

并测定3个批号银翘解毒软胶囊中绿原酸的含量。结果: 3批金银花投料后

乙醇回流提取、减压浓缩、与其他饮片稠膏合并干燥、与挥发油及大豆油制成软胶囊内容物4个环节绿原酸的平均转移率分别为86.1%

77.5%

73.2%

72.8%;相对于上一步的平均保留率分别为86.1%

90.0%

94.6%

99.3%。3批银翘解毒软胶囊每粒平均含绿原酸分别为3.77

3.38

3.86 mg。结论: 该研究可为银翘解毒软胶囊的生产过程控制和含量限量标准制定提供依据。

Abstract

Objective: To study on transfer rate of chlorgenic acid in preparation process of Yinqiao Jiedu soft capsules

and to provide experimental data for preparation process optimization and quality control. Method: According to prescription and technology of Yinqiao Jiedu soft capsules contained in Pharmacopoeia

transfer rate and retention rate of chlorgenic acid in preparation process of Yinqiao Jiedu soft capsules were determined by HPLC. Meanwhile

the content of chlorgenic acid in 3 batches of Yinqiao Jiedu soft capsules were determined by HPLC. Result: Preparation process contained 4 steps: ethanol refluxing

decompression concentration

addition of other herbs’ thickpaste and desiccation

addition of naphtha and bean oil. The mean transfer rate of chlorgenic acid in above steps were 86.1%

77.5%

73.2% and 72.8%;and mean retention rate were 86.1%

90.0%

94.6% and 99.3% respectively. The content of chlorgenic acid in per capsule of Yinqiao Jiedu soft capsules with three batches were 3.77

3.38

3.86 mg. Conclusion: This study could provide reference for quality control and content limit standard establishment in preparation process of Yinqiao Jiedu soft capsules.

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Related Institution

The 3rd Affiliated Hospital of Changchun University of Chinese Medicine

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