Objective: To optimize preparation process of traditional Chinese medicine adhesive plaste. Method: To investigate common technology of traditional Chinese medicine adhesive plaste in preparation process such as safty and comfortable

using single-factor test to investigate solvent which could cause allergy

employing peel strength

softness and paste uniformity as index

using orthogonal test to investigate factors which could influence paste properties as solvent

making gum time and the adding order of each bland matrix part

then optimized condition. Result: The best condition in preparation process was: n-hexane as solvent with 50 mL;2 h as making gum time; firstly

rubber homogenate mixed with softener

then adding viscous agent and filling agent. Conclusion: Optimized owning low allergy rate and high comfortable.