Influence of Hydroxypropyl--cyclodextrin on Solubility of Ginsenoside Rg

MIAO Ju-lian; HUANG Zhao-chang

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Influence of Hydroxypropyl--cyclodextrin on Solubility of Ginsenoside Rg

更新时间：2024-01-04

- Influence of Hydroxypropyl--cyclodextrin on Solubility of Ginsenoside Rg
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 17, Issue 21, Pages: 17-19(2011)
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- Published：2011
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MIAO Ju-lian, HUANG Zhao-chang. Influence of Hydroxypropyl--cyclodextrin on Solubility of Ginsenoside Rg[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(21): 17-19.
DOI：

MIAO Ju-lian, HUANG Zhao-chang. Influence of Hydroxypropyl--cyclodextrin on Solubility of Ginsenoside Rg[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(21): 17-19. DOI：

摘要

目的: 探讨羟丙基-β-环糊精对人参皂苷Rg1溶解度的影响。方法: 用HPLC测定人参皂苷Rg1的含量

设计正交试验考察羟丙基-β-环糊精浓度、温度、搅拌时间

单因素考察pH对人参皂苷Rg1溶解度的影响

对制备的样品进行冻融稳定性考察。结果: 羟丙基-β-环糊精质量浓度40%

温度40 ℃

搅拌时间12 h

pH 7时

人参皂苷Rg1溶解度为353.20 g·L-1

样品冻融稳定性好。结论: 羟丙基-β-环糊精对人参皂苷Rg1溶解度有很大的提高。

Abstract

Objective: To investigate influence of hydroxypropyl-β-cyclodextrin on solubility of ginsenoside Rg1. Method: The content of ginsenoside Rg1 was determined by HPLC

orthogonal test was used to study on concentration of hydroxypropyl-β-cyclodextrin、temperature and stirring time

single factor test was used to analysis the influence of pH to solubility of ginsenoside Rg1

and investigated freeze-thaw stability of samples prepared in these conditions; Result: Optimum conditions for hydroxypropyl-β-cyclodextrin improving solubility of ginsenoside Rg1 were as follows:concentration of hydroxypropyl-β-cyclodextrin 40%

temperature 40 ℃

stirring time 12 h.When pH was 7

solubility of ginsenoside Rg1 was 353.20 g·L-1. Freeze-thaw stability of samples was good. Conclusion: Solubility of ginsenoside Rg1 had greatly improved by using hydroxypropyl-β-cyclodextrin.

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