Objective: To observe the assistant effect of EBFL on S180 tumor mice and explore its possible mechanism. Method: Mice tumor model was applicated; the model groups were divided into EBFL-low dose group (20 mg·kg-1)

EBFL-high dose group (40 mg·kg-1)

and combined group with cyclophosphamide(CTX

20 mg·kg-1

40 mg·kg-1) ig for 2 weeks.Life span

the tumor growth inhibition rate

WBC count

and indexes of immunological founctions

lymphocyte transformations

interleukin-2(IL-2) and tummor necrosis factor-α(TNF-α) levels were observed. Result: Compared with the model group

the EBFL could prolong life span but there was no obvious inhibition effect on S180 tumor. Compared with the CTX group

effect of high dose EBFL group was more obvious and could reverse inhibiting activity of weight

WBC count

immunological function indexes (P<0.05

P<0.01)

EBFL could improve IL-2 levels(P<0.05

P<0.01).The effect of high dose EBFL group was more obvious and could reverse the inhibiting activity of lymphocyte transformation(P<0.01). Conclusion: The EBFL can prolong life span

and attenuate the toxicity of CTX as well as adjust the immunity function.