Preparation and  Evaluation of Puerarin- Polyvinylpyrrolidone K30 Solid Dispersions

HAN Li-wei; ZHANG Gui-ying; GONG Wei-hong; HAN Zhi-dong

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Preparation and Evaluation of Puerarin- Polyvinylpyrrolidone K30 Solid Dispersions

更新时间：2024-01-04

- Preparation and Evaluation of Puerarin- Polyvinylpyrrolidone K30 Solid Dispersions
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 17, Issue 20, Pages: 1-4(2011)
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- Published：2011
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HAN Li-wei, ZHANG Gui-ying, GONG Wei-hong, et al. Preparation and Evaluation of Puerarin- Polyvinylpyrrolidone K30 Solid Dispersions[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(20): 1-4.
DOI：

HAN Li-wei, ZHANG Gui-ying, GONG Wei-hong, et al. Preparation and Evaluation of Puerarin- Polyvinylpyrrolidone K30 Solid Dispersions[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(20): 1-4. DOI：

摘要

目的: 制备葛根素-聚维酮(PVP) K30固体分散体以提高葛根素的溶出速率。方法: 以PVP K30为载体

采用溶剂法制备葛根素-PVP固体分散体

并优选葛根素和PVP K30的最佳比例。通过溶出试验、差示扫描量热法、红外光谱、X射线衍射等方法对固体分散体的性质进行评价。结果: 以最佳比例(葛根素-PVP K30 1 ∶3)制备的固体分散体中葛根素的溶出速率是原料药的2倍;差示扫描量热法、红外光谱及X 射线衍射结果表明固体分散体中葛根素以无定形形式存在

并可能与PVP K30有氢键形成。结论: 采用溶剂法制备葛根素-PVP固体分散体可显著提高葛根素的溶出速率。

Abstract

Objective: To prepare solid dispersions of puerarin with polyvinylpyrrolidone K30 (PVP K30) to improve dissolution of puerarin. Method: Solid dispersion of puerarin-PVP was prepared by solvent method with PVP K30 as carrier. And the best proportion of puerarin to PVP K30 has been optimized.Nature of the solid dispersion was evaluated by dissolution test

differential scanning calorimetry(DSC)

infrared spectroscopy(IR) and X-ray diffraction(XRD). Result: Optimum proportion of puerarin to PVP K30 was 1 ∶3.Dissolution rate of puerarin in the solid dispersions was 2 folds as that of material medicine. The results of DSC

IR and XRD showed that puerarin in the solid dispersion was amorphous form

and hydrogen bond may have been formed between puerarin and PVP K30. Conclusion: Dissolution rate of puerarin could be improved in solid dispersion of puerarin-PVP which prepared by solvent method.

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Related Institution

Institute of Medicinal Plant Development，Chinese Academy of Medical Sciences and Peking Union Medical College

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