Objective: To investigate effects of sophoridine on immune and oxidative injury of acute infection induced by endotoxinin mice. Method: Sixty Kunming mice were randomly divided into 6 groups: normal group

model group

preventive treatment group

low dose

midium dose

and high dose of sophoridine group (n=10

each). Mice in preventive treatment group were injected with 5 mg ·kg-1 sophoridine ip continuously for 6 days

the mice in the rest groups were ip injected 5 mg ·kg-1 saline. One hour after the last administration

mice in all groups except those in group A were ip given endotoxin (9 mg ·kg-1 )to induce acute infection. After 2 h of modeling

sophoridine groups were given ipsophoridine 2.5

5

9 mg ·kg-1 accordingly

the changes in mice were observed; including lung water content; serum interleukin-6 (IL-6)

superoxide dismutase (SOD)

malondialdehyde (MDA) and nitric oxide (NO). Cellular changes in lung tissue was observed by HE staining. Result: Mice treated by sophoridine in each group showed significant improvement in the degree of acute infection

and serum IL-6

MDA

NO levels were lower than those in model group (P<0.05); SOD level was higher than that in model group (P<0.05). Nedium-dosage group was better than the other groups (P<0.05). HE staining showed that the degree of inflammation of the treatments resulted in different degrees of improvement compared with the model group. Conclusion: Sophoridine can reduce the pathological damage in model mice with endotoxin injury to certain degree

and effectively enhance the immune function and the anti-oxidative ability.