Comparison the Content of Evodiamine and Rutaecarpine from Compatible Granule, Compound Granule and Traditional Decoction of Zuojin Pills

ZHANG Xin; JIN Feng-yun; LIANG Guang-yi; HE Zhu-ying; ZHANG Yu

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Comparison the Content of Evodiamine and Rutaecarpine from Compatible Granule, Compound Granule and Traditional Decoction of Zuojin Pills

更新时间：2024-01-04

- Comparison the Content of Evodiamine and Rutaecarpine from Compatible Granule, Compound Granule and Traditional Decoction of Zuojin Pills
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 17, Issue 19, Pages: 67-71(2011)
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- Published：2011
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ZHANG Xin, JIN Feng-yun, LIANG Guang-yi, et al. Comparison the Content of Evodiamine and Rutaecarpine from Compatible Granule, Compound Granule and Traditional Decoction of Zuojin Pills[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(19): 67-71.
DOI：

ZHANG Xin, JIN Feng-yun, LIANG Guang-yi, et al. Comparison the Content of Evodiamine and Rutaecarpine from Compatible Granule, Compound Granule and Traditional Decoction of Zuojin Pills[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(19): 67-71. DOI：

摘要

目的: 比较左金丸传统汤剂、复方颗粒剂与配方颗粒剂中吴茱萸碱和次碱的含量差异。方法: 采用HPLC测定传统汤剂、复方颗粒剂、配方颗粒剂中吴茱萸碱和吴茱萸次碱的含量

并对含量测定的方法进行了考察。结果: HPLC测定吴茱萸碱和次碱在传统汤剂中总质量分数为0.738 0 mg·g-1

在复方颗粒剂中总质量分数为1.379 0 mg·g-1

在配方颗粒剂中总质量分数为0.225 9 mg·g-1。结论: 左金丸传统汤剂、复方颗粒剂、配方颗粒剂吴茱萸碱和吴茱萸次碱总质量分数差异较大:复方颗粒剂>传统汤剂>配方颗粒剂。

Abstract

Objective: To compare the content of evodiamine and rutaecarpine from traditional decoction

compound granules and granule formulation in the Zuojin pills . Method: The content of evodiamine and rutaecarpine in the three forms of Zuojin pills was determined and the method to determine content was established by HPLC. Result: There is 15.455 3 mg·g-1 evodiamine and rutaecarpine in the traditional decoction

21.792 4 mg·g-1 in the compound granules

26.648 3 mg·g-1 in the formulation granules. Conclusion: There are significant differences in the three forms of Zuojin pills. The order is formulation granules>compound granules>traditional decoction.

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