Effect of Berberine on Expressions of Cell Adhesion Molecules in Rats with Middle Cerebral Artery Occlusion

GAN Lu

您当前的位置：

首页 >

文章列表页 >

Effect of Berberine on Expressions of Cell Adhesion Molecules in Rats with Middle Cerebral Artery Occlusion

更新时间：2024-01-04

- Effect of Berberine on Expressions of Cell Adhesion Molecules in Rats with Middle Cerebral Artery Occlusion
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 17, Issue 14, Pages: 240-242(2011)
- 作者机构：
- 作者简介：
- 基金信息：
- DOI：
  CLC：
- Published：2011
- 稿件说明：
移动端阅览
GAN Lu. Effect of Berberine on Expressions of Cell Adhesion Molecules in Rats with Middle Cerebral Artery Occlusion[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(14): 240-242.
DOI：

GAN Lu. Effect of Berberine on Expressions of Cell Adhesion Molecules in Rats with Middle Cerebral Artery Occlusion[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(14): 240-242. DOI：

摘要

目的: 观察大鼠局灶性脑缺血再灌注后缺血脑区细胞间黏附分子-1(ICAM-1)以及P-选择素(P-selectin)的表达和黄连素对两者的影响。方法 :将36只大鼠随机分为3组:假手术组

模型组

给药组。给药组分别于栓塞前15 min和栓塞后2 h

再灌注时ip给黄连素30 mg ·kg-1;模型组和假手术组ip等量生理盐水。采用大脑中动脉线栓法制作大脑局灶缺血再灌注模型。再灌注24 h后取脑

应用免疫组化方法检测ICAM-1和P-selectin的表达。结果 :黄连素能够显著降低缺血再灌注引起的脑梗死体积以及脑组织ICAM-1

P-selectin的表达增高(P<0.05)。其中梗死体积从25%降至17%;ICAM-1阳性细胞百分率从平均65%降至35%;P-selectin从平均60%降至30%。结论 :黄连素能够通过脑缺血再灌注炎性反应的免疫调节机制保护脑缺血再灌注引起的损害。

Abstract

Objective: To investigate the effect of berberine on the expressions of cell adhesion molecules in rats with middle cerebral artery occlusion (MCAO). Method : Tirty-six rats were randomly divided into 3 groups: model group

Sham-operated group and berberine group. We used transient rat MCAO model for brain ischemia. Berberine (30 mg ·kg-1) was given twice intraperitoneally: 15 min pre-occlusion and 2 h post-occlusion at the time of reperfusion. The expressions of ICAM-1 and P-selectin berberine were analyzed by immunohistochemistry method. Result : Berberine significantly decreased the infarct volume and the expressions of ICAM-1 and P-selectin(P<0.05). Conclusion : Berberine may protect the brain injury induced by ischemia-reperfusion through the immunoregulation to the inflammation reaction after brain ischemia.

关键词

Keywords

references

Views

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

Effect of Berberine-Baicalin Combination on Fecal Microbiota Transplantation-induced Type 2 Diabetes Mellitus Due to Internal Accumulation of Dampness-heat in Mice from Perspectives of Gut Microbiota and Metabolomics

Buyang Huanwutang Alleviates Inflammatory Injury After Cerebral Ischemia-reperfusion in Rats via Activating Adiponectin Pathway

Effect of Capsaicin on Cognitive Function of Rats with Focal Cerebral Ischemia by p38 MAPK/COX-2 Signaling Pathway

Analysis of Crucial Transcription Factors of Berberine Against Cerebral Ischemia Based on Transcriptomics and Proteomics

Effect of Xiao Xumingtang Combined with Ultra-acupuncture Along Governor Meridian on Autophagy-related Protein NF-κB p65 in Cerebral Ischemia Reperfusion Model

Related Author

CHEN Mengjie

LIU Yimin

ZHOU Yun

YU Keming

XIA Min

LIU Hongning

JI Yanhua

ZENG Zhijun

Related Institution

Research Center for Differentiation and Development of Traditional Chinese Medicine （TCM） Basic Theory， Jiangxi Province Key Laboratory of TCM Etiopathogenisis， Jiangxi University of Chinese Medicine

School of Basic Medical Sciences， Guangzhou University of Chinese Medicine

Chengde Central Hospital

Institute of Chinese Materia Medica，China Academy of Chinese Medical Sciences

Chinese Institute for Brain Research

AI问答

Postal code：100700
Tel：010-84076882 Email：syfjx_2010@188.com
Technical support is provided by Beijing Founder electronics co., LTD 京ICP备11006657号-10 京公网安备11010802024621
It is recommended to read the content of this site in Chrome&IE9+. Please switch to extreme mode in browser 360.
Cookies We use cookies to help provide and enhance our service and tailor content. By continuing, you agree to the use of cookies.

⁰