Comparison of Immunologic Function of Same Compound Using Astragalus Radix and Using Hedysari Radix

GUI Man-man; ZHANG Li-feng; LI Xue-yan; CHENG Wei-dong

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Comparison of Immunologic Function of Same Compound Using Astragalus Radix and Using Hedysari Radix

更新时间：2024-01-04

- Comparison of Immunologic Function of Same Compound Using Astragalus Radix and Using Hedysari Radix
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 17, Issue 21, Pages: 203-206(2011)
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- Published：2011
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GUI Man-man, ZHANG Li-feng, LI Xue-yan, et al. Comparison of Immunologic Function of Same Compound Using Astragalus Radix and Using Hedysari Radix[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(21): 203-206.
DOI：

GUI Man-man, ZHANG Li-feng, LI Xue-yan, et al. Comparison of Immunologic Function of Same Compound Using Astragalus Radix and Using Hedysari Radix[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(21): 203-206. DOI：

摘要

目的: 比较同一复方用黄芪与用红芪对免疫低下小鼠免疫功能的影响。方法: 取正常昆明种小鼠60只

雌雄各半

随机分为6组:空白对照组、模型组、含黄芪益气养血汤组(6 g·kg-1)、含红芪益气养血汤组(6 g·kg-1)、含黄芪补中益气汤组(4 g·kg-1)、含红芪补中益气汤组(4 g·kg-1)

连续ig 14 d

用药第2天腹腔注射环磷酰胺制备免疫低下小鼠模型

分别比较补中益气汤和益气养血汤用红芪和用黄芪对免疫低下小鼠T淋巴细胞增殖、NK细胞杀伤活性、血清溶血素和血清IL-1

IL-4水平的影响。结果: 这两个复方无论用红芪还是用黄芪均能使免疫抑制小鼠T淋巴细胞增殖、NK细胞杀伤活性、血清溶血素和血清IL-1

IL-4水平提高至正常水平

其中

在T淋巴细胞增殖上

两复方用红芪均比用黄芪作用更为显著(P<0.05)

而在其余指标上两复方无论用红芪还是黄芪均无明显差异。结论: 益气养血汤和补中益气汤在提高细胞免疫功能方面用红芪均比用黄芪作用显著。

Abstract

Objective: To compare the effects of the same compound (Yiqi Yangxue decoction and Buzhong Yiqi decoction) prescription containing Astragali Radix (AR) and Hedysari Radix (HR)

respectively

on immunologic functions of mice. Method: The sixty mice were divided randomly into six groups:the control group

the model group

Yiqi Yangxue decoction containing AR group

Yiqi Yangxue decoction containing HR group

Buzhong Yiqi decoction containing AR group and Buzhong Yiqi decoction containing HR group. The mice were injected peritoneally with cyclophosphamide to establish immunosuppressive model

and spleen lymphocyte Proliferation

IL-1

IL-4 and serum hemolysin level

NK cells activity were observed Result: Afteradministration

the immunologic functions were significantly increased. The compounds congtaining HR were more significant than compounds containingg AR in spleen lymphocyte proliferation

but in other respects

the two compounds whether congtaining AR or HR had no obvious diffference. Conclusion: Both Yiqi Yangxue decoction and Buzhong Yiqi decoction containg HR are better thancompouds congtaining AR in improving cellular immune function.

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