Objective: To explore the interventional mechanism of Chinese herbs Xiaoshuan Tongmai Granules(XSTM) on deep venous thrombosis (DVT)in rats. Method: Seventy two Wistar rats were randomly divided into 4 groups: sham group

DVT model group

XSTM group

Fufang Danshen tablets(DS) group. Venous thrombosis was induced by inferior vena caval occlusion by ligature just below the level of the renal veins. The levels of NF-κB p50 mRNA

NF-κB p65 mRNA and IκBα mRNA in vein wall of all rats were dynamic detected at 1

3

6 days after model built. Result: At the same time

the levels of NF-κB p50 mRNA and NF-κB p65 mRNA in Chinese herbs treatment groups were significant lower than those in model group(P<0.01)

while the level of IκBα mRNA was significantly higher(P<0.01). The levels of NF-κB p50 mRNA and NF-κB p65 mRNA were increased the decreasing trend after model induced

and reached the peak at 3rd day after ligature(P<0.01) in all groups. But the levels of IκBα mRNA were decreased the increasing trend after model induced

and reached the low at 3rd day after ligature(P<0.01) in all groups. At the same time

the levels of NF-κB p50 mRNA and NF-κB p65 mRNA in XSTM group were significantly lower than those in DS group(P<0.01)

while the level of IκBα mRNA in XSTM group was significantly higher(P<0.01). Conclusion: It suggested that XSTM could intervene the system of NF-κB p / IκB to supress inflammatory reaction and thrombosis.