Objective: By summarizing the latest research development on pharmacological effects and hepatotoxicity of Bupleurum saikosaponin

to provide the literature accordance and research ideas. Method: By searching the CNKI and NCBI databases

the related references in recent 5-10 years both at home and abroad about Bupleurum saikosaponin were collected

analyzed and summarized. Result : Bupleurum saikosaponin were the mainly chemical components of Bupleurum which had the hapatoprotective effect; the hepatotoxicity of Bupleurum saikosaponin were gradually recognized on the process of clinical application and modern research

and the hepatic damage mechanism and channel were mainly related with the multi-channel oxdative injury. Conclusion : Only in the process of effect expression and the effctive materials separation and control of Bupleurun when studying its toxicity and toxic materials

it could propose the early adverse reaction warning program and early diagonosis treatment measures properly and guarantee the clinical use of Bupleurum safely

so that to deal with relative problems of its hepatotoxicity both at home and abroad scientifically.