Objective: To observe the impact of patients in disease of idiopathic thrombocytopenic purpura (ITP) of platelet count

marrow megakaryocyte count and class

T lymphocyte subset in peripheral blood on treatment with Yiqi Tongyang decoction. Method : It is designed to use guinea pig anti-mouse serum (APS) to inject to the mouse in order to induce the ITP mouse model. Then Yiqi Tongyang decoctions treatment group with 3 levels of greate

media and small is given.Separately to the treatement

the normal control group and model control group are also set

and all 3 group are maintained its treatment for continuel 14 days. The blood cell counter is used to detect platelet count

to observe megakaryocyte configuration by microscope

to count the megakaryocyte in mouse thighbone by plastic embedding and to detect T lymphocyte subset by cytometer. Result : In model mouse group

platelet

CD3+CD4+T cell are reduced significantely

and CD3+CD8+T cells are significantly increased. In Yiqi Tongyang mouse groups

platelet count increased significant

producing platelet megakaryocyte and CD4+/CD8+ were obviously increased. Megakaryocyte count reduced

CD3+CD4+T cell increased

and CD3+CD8+ T lymphocyte are significantly decreased

and CD4+/CD8+value is increased. Conclusion : Yiqi Tongyang decoction improves platelet count in ITP model mouse group

increase platelet producing megakaryocyte ratio

meliorate unbalance of T lymphocyte

that means the Yiqi Tongyang decoction is approved to be effective of treating ITP patients clearly in this study.