Anti-stress Effect of  Oral Liquidin Mice with Yang Deficient

LIU Zhen-zhong; CAO Dan-yan; ZHU Guang-hua; TANG Xiao-jiang

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Anti-stress Effect of Oral Liquidin Mice with Yang Deficient

更新时间：2024-01-04

- Anti-stress Effect of Oral Liquidin Mice with Yang Deficient
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 17, Issue 18, Pages: 187-189(2011)
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- Published：2011
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LIU Zhen-zhong, CAO Dan-yan, ZHU Guang-hua, et al. Anti-stress Effect of Oral Liquidin Mice with Yang Deficient[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(18): 187-189.
DOI：

LIU Zhen-zhong, CAO Dan-yan, ZHU Guang-hua, et al. Anti-stress Effect of Oral Liquidin Mice with Yang Deficient[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(18): 187-189. DOI：

摘要

目的: 研究红景天口服液对氢化可的松致小鼠阳虚模型动物的保护作用。方法: 雄性昆明种小鼠50只

按体重随机分为5组

每组10只

空白对照组、模型对照组、男宝胶囊组、红景天低、高剂量组。im氢化可的松25 mg ·kg-1每天1次

连续给药5 d建立小鼠阳虚模型。造模后ig给予生理盐水(空白对照、模型对照)、男宝胶囊2.0 g ·kg-1、红景天口服液低、高(2.48

24.80 g ·kg-1)剂量

连续7 d

每天2次。观察动物的体重、性器官、附性器官和免疫器官质量系数的变化

测定自主活动次数、体温和低温游泳时间等指标。结果: 造模动物的体重、活动次数、体温、低温游泳时间、胸腺和附性器官指数较空白对照组有明显的下降(P<0.01);ig红景天口服液后

体重、体温、胸腺和附性器官指数较模型对照组有明显的增加(P<0.01或P<0.05)。结论: 红景天口服液对于im氢化可的松致阳虚小鼠动物模型可能具有抗应激作用。

Abstract

Objective: To observe the protective effect of Rhodiola crenulate oral liquid (RCOL) on Yang deficiency induced by hydrocortisone in rats. Method: Fifty Kunming male mice were randomly divided in 5 groups with 10 mice each group. The mouse model of Yang deficiency was induced by intramuscular injection of hydrocortisone (25 mg ·kg-1) for 5 days. On the fifth day of administration

normal saline (blank control and model control) Nan-bao capsule

RCOL (2.48

24.80 g ·kg-1) were orally treated for 7 days

twice a day. The weight of mice

the coefficient of sex organs and immune organs

independent activity

the body temperature and the swimming time in cold water

were observed. Result: The weight

activity times

body temperature

the swimming time in cold water

the indexes of thymus and accessory sex organs in the model group were lower than that those in blank group (P<0.01). The weight

body temperature

the indexes of thymus and accessory sex organs in RCOL groups were higher than that in model group (P<0.01 orP<0.05). Conclusion: RCOL has anti-stress effect on Yang deficient induced by hydrocortisone in mice.

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Related Author

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Related Institution

College of Basic Medicine and Forensic Medicine， Henan University of Science and Technology

School of Chinese Materia Medica， Beijing University of Chinese Medicine

School of Traditional Chinese Medicine， Beijing University of Chinese Medicine

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