Objective: To investigate the effect of Yangxin Kaiyu tablet (YXKY Tablet) on behavior and memory in chronic depression model rats. Method: Chronic stress depression rat model was established by chronic and mild unpredictable stressors and housed seperately as described in the literature.The preference for 1% sucrose solution

Morris water maze and space search test was carried out.SD rats were randomly divided into control group

model group

fluoxetine hydrochloride group

and three dose groups of YXKY tablet (1 500

750

375 mg·kg-1).YXKY tablet were administered i.g.once per day for 28 days; same volume of water was given to model group and control group. Result: The preference for 1% sucrose solution was increased in 375

750 mg·kg -1 of YXKY tablet groups. Navigation latency in Morris water maze was shortened in three dose groups of YXKY tablet.Lasting time

distance

and total times of crossing the target region in the fourth quadrant were increased significantly in 375

750 mg·kg-1 of YXKY tablet groups.There was statistically significant difference between medication treatment groups and model groups (P <0.05 or P <0.01). Conclusion: YXKY tablet could improve depressive rats’ behavior and memory.The experimental result provided a basis for clinical treatment to depression.