Objective: To observe the effect of Dracocephalum moldavica petroleum ether extract and ethyl acetate extract on hyperlipidemia. Method: The rat hyperlipidemia model was established by administration of high rat emulsion. The following indexes were determined: total cholesterol(TC)

triglyceride (TG)

low density ipoprotein-cholesterol(LDL-C)

high density lipoprotein-cholesterol (HDL-C)

malondialdehyde (MDA)

superoxide dismutase (SOD)

alanine aminotransferase (ALT)

aspartate aminotransferase (AST)

the malondialdehyde (MDA) and superoxide dismutase (SOD) of hepatic tissue after administration of 10 weeks therapy Light microscope was used to observe the steatosis of hepatic tissue in hyperlipidemia rat. Result: Compared with model group

D. moldavica petroleum ether extract could decrease the serum level of TG

LDL-C

ALT

AST

MDA (P<0.01 or P<0.05)

increase the serum level of HDL-C

SOD (P<0.01)

increase the liver homogenate level of SOD (P<0.05)

and lower the liver homogenate level of MDA (P<0.01);Compared with model group

D. moldavica ethyl acetate extract could lower the serum level of TC

LDL-C

ALT

AST

MDA (P<0.01)

increase the serum level of SOD (P< 0.05)

and increase the liver homogenate level of SOD(P<0.01)

lower the liver homogenate level of MDA (P<0.01). Conclusion: D. moldavica extract can regulate lipid metabolism disorders and reduce the incidence of fatty liver and its modulation may be related to its antioxidant capacity.