Effect of Dosage Form and Administration Route to Distribution of Ginsenoside Rg in Serum and Brain of Rats
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Effect of Dosage Form and Administration Route to Distribution of Ginsenoside Rg in Serum and Brain of Rats
Chinese Journal of Experimental Traditional Medical FormulaeVol. 17, Issue 14, Pages: 43-46(2011)
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Published:2011
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CHEN Xin-mei. Effect of Dosage Form and Administration Route to Distribution of Ginsenoside Rg in Serum and Brain of Rats[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(14): 43-46.
DOI:
CHEN Xin-mei. Effect of Dosage Form and Administration Route to Distribution of Ginsenoside Rg in Serum and Brain of Rats[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(14): 43-46.DOI:
Effect of Dosage Form and Administration Route to Distribution of Ginsenoside Rg in Serum and Brain of Rats
Objective: To discuss the effect of dosage form and administration route on the distribution of ginsenoside Rg1 (GRg1) in serum and brain of the rats. Method : Compared with GRg1 saline solution administrated from nasal route and oral route
GRg1 nasal spray was administrated from nasal route in rats. The concentration of GRg1 in the serum and brain was detected by HPLC-UV. The data was analyzed by the Wagner-Nelson method. Result : The distribution and transport efficiency of GRg1 was improved 5.05 and 2.50 times respectively by nasal administration route. The distribution and transport efficiency of GRg1 was improved 11.80 and 3.35 times respectively by nasal spray. Conclusion : The bio-availability of GRg1 can be improved dramatically by the nasal administration route and nasal spray.