Effect of Shuyu Wan on Immunity of Murine AIDS Induced by Friend Murine Leukemia Virus in Mice
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Effect of Shuyu Wan on Immunity of Murine AIDS Induced by Friend Murine Leukemia Virus in Mice
Chinese Journal of Experimental Traditional Medical FormulaeVol. 17, Issue 19, Pages: 191-194(2011)
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Published:2011
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REN Zhou-xin, XU Qian-lei, LI Qing-ya, et al. Effect of Shuyu Wan on Immunity of Murine AIDS Induced by Friend Murine Leukemia Virus in Mice[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(19): 191-194.
DOI:
REN Zhou-xin, XU Qian-lei, LI Qing-ya, et al. Effect of Shuyu Wan on Immunity of Murine AIDS Induced by Friend Murine Leukemia Virus in Mice[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(19): 191-194.DOI:
Effect of Shuyu Wan on Immunity of Murine AIDS Induced by Friend Murine Leukemia Virus in Mice
Objective: To observe the effect of Shuyu Wan on the immunity of murine AIDS(MAIDS)induced by the Friend murine leukemia virus(FLV). Method: Experimental model was established by inoculated intraperitoneally(ip)with FLV in mice. Meanwhile
treatment groups were intragastric administrated with Shuyu Wan. Three weeks later
blood was withdrawn to assay interleukin-2(IL-2)
interferon(IFN)-γ and IL-6 by enzyme linked immunosortent assay(ELISA). Percentage of cluster of differentiation 4+(CD4+)T lymphocyte and CD8+T lymphocyte were determined by flow cytometry. In addition
some mice were injected cyclophosphamide(CTX)and given Shuyu Wan for 5 days
then
leucocytes
hemoglobins
and erythrocytes were dectected. Result: FLV model group showed no evident differences to the treatment groups. But compared with CTX group
the amount of leucocytes
hemoglobins
and erythrocytes were higher markedly in Shuyu Wan groups(P<0.05). Conclusion: Shuyu Wan could not ameliorate immunity of MAIDS induced by the Friend murine leukemia virus. Friend virus infection model might not be appropriate for anti-HIV study by traditional Chinese medicine.
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