Study on Pharmacokinetic of Bismuth in Weishu San in Rat

WU Yan-ping; LIN Xu-kai

您当前的位置：

首页 >

文章列表页 >

Study on Pharmacokinetic of Bismuth in Weishu San in Rat

更新时间：2024-01-04

- Study on Pharmacokinetic of Bismuth in Weishu San in Rat
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 17, Issue 22, Pages: 108-110(2011)
- 作者机构：
- 作者简介：
- 基金信息：
- DOI：
  CLC：
- Published：2011
- 稿件说明：
移动端阅览
WU Yan-ping, LIN Xu-kai. Study on Pharmacokinetic of Bismuth in Weishu San in Rat[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(22): 108-110.
DOI：

WU Yan-ping, LIN Xu-kai. Study on Pharmacokinetic of Bismuth in Weishu San in Rat[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(22): 108-110. DOI：

摘要

目的: 通过研究胃舒散中重金属铋在大鼠血液中的分布代谢情况

为研究该物质在体内的蓄积情况提供实验依据。方法: 取健康大鼠

灌服胃舒散混悬液

分别于给药前及给药后5

120

180

240 min尾静脉采血。用电感耦合等离子体质谱仪(ICP-MS)检测铋含量

进行分析。结果: 测得数据显示铋的血药浓度在0.5 h左右达到高峰

达峰浓度在15 μg·L-1左右

然后快速下降

7 h降至较低水平。铋在大鼠体内的吸收半衰期14.691 min

消除半衰期293.422 min

铋在大鼠体内的血浆药物总清除率1 571.044 L·min-1·kg-1。AUC 2 063.515 μg·L-1·min-1。结论: 铋在大鼠体内的药代动力学模型符合一房二室模型。

Abstract

Objective: To study the distribution and metabolism of bismuth in Weishu San in rat blood

providing the basis for further clinical studies. Method: Blood sample was collected at 5

120

180

240 min after feeding healthy rats with Weishu San suspension solution. The bismuth content detected by inductively coupled plasma mass spectrometry (ICP-MS). Result: Measured data show that plasma concentrations of bismuth reached a peak at 0.5 h

peak concentration of 15 μg·L-1 or so

and then decreased rapidly

down to a lower level at 7 h. The absorption half-life of bismuth in rats was 14.691 min and elimination half-life was 293.422 min. The total body clearance of bismuth in rats achieve 1 571.044 L·min-1·kg-1. AUC was 2 063. 515 μg·L-1·min-1. Conclusion: Pharmacokinetic model of bismuth in rat meets two-compartment model with first absorption.

关键词

Keywords

references

Views

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

Hedysari Radix Polysaccharide Regulates Apoptosis of Smooth Muscle Cells in Gastric Antrum of Rat Model of Diabetic Gastroparesis via IGF-1/PI3K/Akt Signaling Pathway

Effect of Notoginseng Total Saponins on Apoptosis of Mammary Gland Cells in Rats with Mammary Gland Hyperplasia by Regulating PI3K/Akt/mTOR Pathway

Intervention Effect and Mechanism of Qingmei Compound on Acute Gouty Arthritis Based on NLRP3 Pathway

Effect of Huazhuo Jiedu Shugan Prescription on Learning， Memory， and PI3K/Akt/GSK-3β Signaling Pathway in Epileptic Rats

Effect of Epimedii Folium Total Flavonoids on Angiogenesis of Ischemic Myocardium in Rats After Acute Myocardial Infarction

Related Author

MIAO Linlin

WAN Shengfang

ZHANG Lei

LI Rongke

WEI Zhaohui

ZHU Xiaoli

AN Hui

GONG Zixing

Related Institution

School of Basic Medicine， Gansu University of Chinese Medicine

Gansu Key Laboratory of Traditional Chinese Medicine Formula Innovation and Transformation

Key Laboratory of Dunhuang Medicine， Ministry of Education， Gansu University of Chinese Medicine

Hebei Province Hospital of Traditional Chinese Medicine

Yantai New Era Health Industry Co.Ltd.

AI问答

Postal code：100700
Tel：010-84076882 Email：syfjx_2010@188.com
Technical support is provided by Beijing Founder electronics co., LTD 京ICP备11006657号-10 京公网安备11010802024621
It is recommended to read the content of this site in Chrome&IE9+. Please switch to extreme mode in browser 360.
Cookies We use cookies to help provide and enhance our service and tailor content. By continuing, you agree to the use of cookies.

⁰