Preparation and Sustained Release of Theophylline -Cyclodextrin Polymer Microspheres Inclusion Compound

YANG Li-yan; YANG Wei; YOU Jing; ZHANG Jing-shu

您当前的位置：

首页 >

文章列表页 >

Preparation and Sustained Release of Theophylline -Cyclodextrin Polymer Microspheres Inclusion Compound

更新时间：2024-01-04

- Preparation and Sustained Release of Theophylline -Cyclodextrin Polymer Microspheres Inclusion Compound
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 17, Issue 16, Pages: 8-12(2011)
- 作者机构：
- 作者简介：
- 基金信息：
- DOI：
  CLC：
- Published：2011
- 稿件说明：
移动端阅览
YANG Li-yan, YANG Wei, YOU Jing, et al. Preparation and Sustained Release of Theophylline -Cyclodextrin Polymer Microspheres Inclusion Compound[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(16): 8-12.
DOI：

YANG Li-yan, YANG Wei, YOU Jing, et al. Preparation and Sustained Release of Theophylline -Cyclodextrin Polymer Microspheres Inclusion Compound[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(16): 8-12. DOI：

摘要

目的: 以β-环糊精为原料

采用共沉淀法制备茶碱β环糊精聚合物(CDP)微球。方法: 通过L9(34)正交试验设计对制备工艺进行了优化

并采用体外动态释药法评价其释药特征。分别用激光粒度分布仪、红外光谱仪、综合热分析仪、X射线衍射仪对茶碱β-CDP载药微球进行表征。结果: 最佳工艺条件是β-CDP微球1 g、茶碱 0.02 g、蒸馏水30 mL、反应时间3 h、温度60 ℃。合成的载药微球形态良好

平均粒径为 162.35 μm

载药量为1.79%

包封率为89.50%。茶碱β-CDP微球体外释药规律符合一级释放方程和Korsmeyer-Peppas模型方程。结论: 茶碱载药微球具有一定缓释效果

其制备方法合理可行。

Abstract

Objective: Theophylline β-cyclodextrin polymer(β-CDP) microspheres inclusion compound was prepared with β-cyclodextrin as material by coprecipitation method. Method: The preparation process was optimized through the L9(34) orthogonal experimental design and theophylline release from theophylline β-cyclodextrin polymer microspheres was evaluated in vitro.Theophylline β-cyclodextrin polymer microspheres was characterized by laser particle analyzer

FT-IR spectroscopy

thermogravimetric analysis (TGA) and X-ray diffraction (XRD). Result: The optimal procedure was β-CDP microspheres 1 g

theophylline 0.02 g

water 30 mL

time 3 h

and inclusion temperature 60 ℃. Average diameter of optimized products was 162.35 μm and the drug loading and drug encapsulation efficiency were 1.79% and 89.50% respectively. The drug release profile could be described by first-order release equation and Korsmeyer-Peppas equation. Conclusion: The sustained release microspheres had determinate effects be observed and this preparation method was reasonable and feasible.

关键词

Keywords

references

Views

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

Study on Drug-releasing of Shuanghuanglian in-situ Gel

Related Author

CHEN Liang-mian

WANG Jin-yu

TONG Yan

LIU De-wen

Related Institution

No data

AI问答

Postal code：100700
Tel：010-84076882 Email：syfjx_2010@188.com
Technical support is provided by Beijing Founder electronics co., LTD 京ICP备11006657号-10 京公网安备11010802024621
It is recommended to read the content of this site in Chrome&IE9+. Please switch to extreme mode in browser 360.
Cookies We use cookies to help provide and enhance our service and tailor content. By continuing, you agree to the use of cookies.

⁰