The Effect of Shuyu Granules on Monoamine Neurotransmitters and Inflammatory Factors in Hippocampus in Post-stroke Depression Rats

SHEN Xiao-ming; HAN Ning; MA Yun-zhi; JIA Kui; LI Dong-yu; SHI Ji-xin; LAN Rui; ZHANG Ke-ke; MENG Chuang; REN Ying-guo

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The Effect of Shuyu Granules on Monoamine Neurotransmitters and Inflammatory Factors in Hippocampus in Post-stroke Depression Rats

更新时间：2024-01-04

- The Effect of Shuyu Granules on Monoamine Neurotransmitters and Inflammatory Factors in Hippocampus in Post-stroke Depression Rats
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 17, Issue 19, Pages: 177-180(2011)
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- Published：2011
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SHEN Xiao-ming, HAN Ning, MA Yun-zhi, et al. The Effect of Shuyu Granules on Monoamine Neurotransmitters and Inflammatory Factors in Hippocampus in Post-stroke Depression Rats[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(19): 177-180.
DOI：

SHEN Xiao-ming, HAN Ning, MA Yun-zhi, et al. The Effect of Shuyu Granules on Monoamine Neurotransmitters and Inflammatory Factors in Hippocampus in Post-stroke Depression Rats[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(19): 177-180. DOI：

摘要

目的: 探讨舒郁颗粒对卒中后抑郁(PSD)大鼠模型行为学、海马单胺类神经递质及肿瘤坏死因子α(TNF-α)、白细胞介素1β(IL-1β)的影响。方法: 对成年雄性SD大鼠采用双侧颈总动脉永久性结扎后予以行为限制的方法制备PSD大鼠模型

将造模成功的雄性SD大鼠随机分为模型组、假手术组、氟西汀组以及舒郁颗粒高、中、低剂量组共6组

分别给予蒸馏水、氟西汀溶液及舒郁颗粒高、中、低(2.4

1.2

0.6 g·kg-1)剂量ig

22 d后观察大鼠自发性行为改变、海马区单胺类神经递质及TNF-α

IL-1β含量的变化。结果: 检测大鼠行为学变化

舒郁颗粒高、中、低剂量组与氟西汀组各项指标无明显差异

与模型组比较差异有统计学意义(P<0.05)。检测大鼠脑组织海马区单胺类神经递质及炎症因子的含量

与模型组比较

舒郁颗粒高、中、低剂量组去甲肾上腺素(NE)、多巴胺(DA)、5-羟色胺(5-HT)水平上升有显著性差异(P<0.05)

IL-1β及TNF-α含量均显著下降(P<0.05)

而与假手术组无明显差异;与氟西汀组各项指标无明显差异。结论: 舒郁颗粒可明显改善卒中后抑郁大鼠的行为

提高卒中后抑郁大鼠模型海马单胺类神经递质水平

降低炎症细胞因子含量水平。

Abstract

Objective: To investgate the effect of Shuyu granules on monoamine neurotransmitters and inflammatory factors in hippocampus of post-stroke depression(PSD)rats. Method: PSD model was established by permanent bilateral common carotid artery ligation together with a behavior limitation. The spontaneous behavior was observed and monoamine neurotransmitters in the hippocampus and tumor necrosis factor-α(TNF-α)and interleukin 1β(IL-1β)were detected in 22 days after surgery. Result: Compared with the model group

there were significant differences in the behavior ability of PSD rats in three dose groups of Shuyu granules and Fluoxetine group(P<0.05). Compared with the model group

norepinephrine(NE)

dopamine(DA)

serotonin(5-HT) were significantly increased(P<0.05)in the three dose groups of Shuyu Granules.

IL-1β and TNF-α were significantly decreased(P<0.05). Conclusion: Shuyu granuls could increase monoamine neurotransmitters and reduce cytokines and improve the spontaneous behavior in post-stroke depression rats.

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