Effect of Jiawei Taohe Chengqi Decoction on Learning and Memory in Rats with Alzheimer’s Disease Induced by A

WANG Chun; DONG Xiu; LIN Da-yong; MA Xian-de; QU Jing

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Effect of Jiawei Taohe Chengqi Decoction on Learning and Memory in Rats with Alzheimer’s Disease Induced by A

更新时间：2024-01-04

- Effect of Jiawei Taohe Chengqi Decoction on Learning and Memory in Rats with Alzheimer’s Disease Induced by A
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 17, Issue 19, Pages: 174-176(2011)
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- Published：2011
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WANG Chun, DONG Xiu, LIN Da-yong, et al. Effect of Jiawei Taohe Chengqi Decoction on Learning and Memory in Rats with Alzheimer’s Disease Induced by A[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(19): 174-176.
DOI：

WANG Chun, DONG Xiu, LIN Da-yong, et al. Effect of Jiawei Taohe Chengqi Decoction on Learning and Memory in Rats with Alzheimer’s Disease Induced by A[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(19): 174-176. DOI：

摘要

目的: 观察加味桃核承气汤对β-淀粉样蛋白(Aβ)损伤大鼠学习记忆能力的影响

并探讨其作用机制。方法: SD大鼠随机分成3组

利用立体定位仪将Aβ1-42全长肽注射到大鼠双侧海马

构建Aβ损伤痴呆鼠模型(即Aβ1-42模型组);同时注射Aβ42-1反序列全长肽(即Aβ42-1对照组)和磷酸盐缓冲液(PBS)对照组(PBS对照组)。造模7 d后

每组再分成2个亚组

即加味桃核承气汤治疗组和空白组

分别以灌胃法(ig)给予加味桃核承气汤20 mL(20 g·kg-1)和同样体积的生理盐水

1次/d

连续21 d。利用水迷宫定位航行实验检测各组大鼠学习记忆能力情况

并应用Westen blotting方法检测各组大鼠海马组织中Tau

p-Tau蛋白的表达情况。结果: 在定位航行实验中

Aβ1-42模型组大鼠平均逃避潜伏期(59.20±10.12)s长于Aβ42-1对照组(34.26±15.23)s和PBS对照组(32.07±9.50)s(P<0.05);Aβ1-42模型组大鼠应用加味桃核承气汤治疗后

平均逃避潜伏期明显缩短

与给予生理盐水组相比存在统计学差异(P<0.05);而应用加味桃核承气汤治疗后Aβ42-1对照组和PBS对照组的平均逃避潜伏期改变不明显。此外

应用加味桃核承气汤治疗的Aβ1-42模型组大鼠海马组织中Tau和p-Tau蛋白的表达水平也低于生理盐水组。结论: 加味桃核承气汤可能通过降低脑组织中Tau蛋白表达

抑制Tau蛋白异常磷酸化

提高痴呆大鼠学习记忆能力。

Abstract

Objective: To observe the effect of Jiawei Taohe Chengqi decoction(JWTHCQD)on learning and memory in Aβ1-42 induced Alzheimer’s disease(AD)in rats and study its mechanism. Method: Rats were injected bilaterally of aggregated Aβ1-42

Aβ42-1 or PBS into hippocampus mounted using stereotaxic apparatus for AD model establishment. Three groups rats were treated with JWTHCQD(20 g·kg-1)or saline solution respectively. After 21 days

learning and memory ability of the rats were determined by Morris water maze test. And hippocampus tissue specimens for each group were harvested for Tau and p-Tau protein detcted by Western blotting. Result: In place navigation test

the time of escape latency was significantly longer in Aβ1-42 group than that in other groups(P<0.05)

but shorter in JWTHCQD treated Aβ1-42 group(P<0.05). Besides

Tau and p-Tau protein were all down-regulation in the Aβ1-42 group after JWTHCQD treatment. Conclusion: JWTHCQD could improve the learning and memory in AD model rats by regulating Tau and p-Tau protein expression.

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