Targeting Investigation for Freeze-dried Injection of Oxymatrine- Polybutylcyanoacrylate- Nanoparticles

NI Chen; LAI Chun-li; WANG Qian; XIONG Yi-hua; LAI Xiao-ping

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Targeting Investigation for Freeze-dried Injection of Oxymatrine- Polybutylcyanoacrylate- Nanoparticles

更新时间：2024-01-04

- Targeting Investigation for Freeze-dried Injection of Oxymatrine- Polybutylcyanoacrylate- Nanoparticles
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 17, Issue 16, Pages: 203-206(2011)
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- Published：2011
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NI Chen, LAI Chun-li, WANG Qian, et al. Targeting Investigation for Freeze-dried Injection of Oxymatrine- Polybutylcyanoacrylate- Nanoparticles[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(16): 203-206.
DOI：

NI Chen, LAI Chun-li, WANG Qian, et al. Targeting Investigation for Freeze-dried Injection of Oxymatrine- Polybutylcyanoacrylate- Nanoparticles[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(16): 203-206. DOI：

摘要

目的: 研究氧化苦参碱微球(OMAT-PBCA-NP)冻干针剂的动物器官靶向性。方法: 采用高效液相色谱法测定给药大鼠各主要脏器的氧化苦参碱含量。色谱条件:Kromasil C18柱(4.60 mm× 250 mm

5 μm)

流动相甲醇-水-三乙胺(50∶50∶0.02)

柱温20 ℃

检测波长210 nm

流速1 mL·min-1

进样量为10 μL。结果: 氧化苦参碱在50~400 mg·L-1线性关系良好(r=0.999 0)

在30 min

8 h等时间点中

氧化苦参碱在肝内的含量最高

与其他脏器含量有极显著性差异(P＜0.01)。结论 OMAT-PBCA-NP具有良好的肝脏靶向性。

Abstract

Objective: To study the organ targeting for freeze-dried injection of Oxymatrine- Polybutylcyanoacrylate-Nanoparticles (OMAT-PBCA-NP) in rats. Method: The content of oxymatrine in major organs of rats after injected with OMAT-PBCA-NP was investigated by high performance liquid chromatography. HPLC was carried out on a Kromasil C18 column (4.60 mm×250 mm

5 μm)with the mobile phase consisting of methanol and water and triethylamine(50∶50∶0.02)

the column temperature was 20 ℃ and UV detection wavelength was 210 nm

the flow was 1 mL·min-1 and the injection volume was 10 μL. Result: The calibration curve of oxymatrine was linear in the concentration range of 50-400 mg·L-1(r=0.999 0)

in 30 min

8 h

the content of oxymatrine was highest in the liver with significant difference from other organs (P＜0.01). Conclusion: OMAT-PBCA-NP has good targeting for liver.

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