The effects of Cuyu Granule on Nitric Oxide,Gastrin in Serum and Plasma Neurotensin in Rats with Gastric Ulcer Induced by Acetic Acid
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The effects of Cuyu Granule on Nitric Oxide,Gastrin in Serum and Plasma Neurotensin in Rats with Gastric Ulcer Induced by Acetic Acid
Chinese Journal of Experimental Traditional Medical FormulaeVol. 17, Issue 17, Pages: 181-184(2011)
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Published:2011
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FENG Yun-xia, SHI Zhao-hong, ZHANG Jie-mei, et al. The effects of Cuyu Granule on Nitric Oxide,Gastrin in Serum and Plasma Neurotensin in Rats with Gastric Ulcer Induced by Acetic Acid[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(17): 181-184.
DOI:
FENG Yun-xia, SHI Zhao-hong, ZHANG Jie-mei, et al. The effects of Cuyu Granule on Nitric Oxide,Gastrin in Serum and Plasma Neurotensin in Rats with Gastric Ulcer Induced by Acetic Acid[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(17): 181-184.DOI:
The effects of Cuyu Granule on Nitric Oxide,Gastrin in Serum and Plasma Neurotensin in Rats with Gastric Ulcer Induced by Acetic Acid
Objective: To investigate the effect of Cuyu granule on the nitric oxide(NO)
gastrin(GAS) in serum and neurotensin(NT) in blood plasma in rats with gastric ulcer induced by acetic acid. Method: The rats were randomly divided into four groups:control group
model group
Cuyu granule(28.8 g ·kg-1)group and Ranitidine(27 mg ·kg-1)group. The rat model of gastric ulcer was induced by acetic acid.The pH meter was used to measure the pH of stomach liquid. The content of gastrin in serum and NT in blood plasma were detected with radio immunoassay. The level of NO in serum was determined by the method of nitric acid reductase. Result: Compared with model group
the pH of stomach liquid
the contents of gastrin and NO in Cuyu granule group were increased as NT in blood plasma decreased significantly (P<0.05). Compared with ranitidine group
the pH of stomach liquid
the content of gastrin in serum and NT in blood plasma of Cuyu granule group showed no differences
but the level of NO in serum was increased significantly (P<0.05). Conclusion: Cuyu granule can ameliorate the quality of reborn mucosa and increase pHin treatment of gastric ulcer. The mechanism may be related to regulation of NO
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Related Institution
The Second Affiliated Hospital of Heilongjiang University of Chinese Medicine
School of Pharmacy, Academy of Chinese Medical Sciences, Henan University of Chinese Medicine
School of Pharmacy of Anhui University of Chinese Medicine,Anhui Province Key Laboratory of Chinese Medicinal Compounds,Synergetic Innovation Center of Anhui Authentic Chinese Medicine, Heifei
Academy of Traditional Chinese Medicine,Henan University of Chinese Medicine
Li Zhenhua Institute of Academic Thought, Henan University of Chinese Medicine