Objective: To determine niccolum in sorbitol with flame-atomic absorption spectroscopy

and set up measurement uncertainty of the method. Method: Niccolum in sorbitol distilled by methylisobutylketone was determined by flame-atomic absorption spectroscopy

and set up measurement uncertainty of the method simultaneously. Result: Nickel content is 0.035 1

0.027 3 μg·g-1 with RSD 0.54%

limit of quantitation is 0.02 mg·L-1

recovery is 100.15%. Specificity test showed no impurity disturbances. The percent of uncertainty of sample solution and atomic absorption spectrometer is 84.01% and 15.99%. Conclusion: This method possesses excellence of simplify manipulation

high veracity and nicer repeatability. It can content the need of niccolum determination and offer basis for quality control of officinal accessories sorbitol.