Study on Characteristics of Particle Size Distribution in O/W Microemulsion Gel

Yi Hong; YANG Hua; GAO Jin; LIU Shu-zhi; DU Mao-bo

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Study on Characteristics of Particle Size Distribution in O/W Microemulsion Gel

更新时间：2024-01-04

- Study on Characteristics of Particle Size Distribution in O/W Microemulsion Gel
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 17, Issue 17, Pages: 1-4(2011)
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- Published：2011
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Yi Hong, YANG Hua, GAO Jin, et al. Study on Characteristics of Particle Size Distribution in O/W Microemulsion Gel[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(17): 1-4.
DOI：

Yi Hong, YANG Hua, GAO Jin, et al. Study on Characteristics of Particle Size Distribution in O/W Microemulsion Gel[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(17): 1-4. DOI：

摘要

目的: 研究O/W型微乳凝胶的粒度分布特性及其与普通水凝胶的区别。方法: O/W型微乳凝胶样品经稀释后采用动态光散射法进行粒度检测

通过对样品稀释方法和条件进行考察

确定了样品检测方法;对含不同凝胶基质的微乳凝胶和不同微乳处方配制成的微乳凝胶进行粒度测定

并与普通水凝胶进行比较。结果: O/W型微乳凝胶用水稀释100倍后可进行平均粒度测定

平均粒度分布在10~100 nm;微乳凝胶与其同处方微乳的粒度分布相近;与普通水凝胶有明显区别。结论: 粒度测定可作为微乳凝胶检测指标之一。

Abstract

Objective: To study the characteristics of particle size distribution in O/W microemulsion gel and its difference from hydrogel. Method: The diluted O/W microemulsion gel was detected by using dynamic light scattering. The pretreatment methods and conditions of sample were investigated to determine its detection method;Average size of microemulsion gels with different gel matrix and different microemulsion formulae were tested

which can be used to compare with hydrogel. Result: The result showed that average size of O/W microemulsion gels can be determined after being diluted 100 times. Its average particle size was between 10 nm and 100 nm.The size distribution of microemulsion gel is similar to the same formulae of microemulsion

which was obviously different from hydrogel. Conclusion: Size measurement can be used as a testing index for microemulsion gel.

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