Comparison of Clinical Indications Simulating Deficiency of Both Qi and Yin Syndrome Induced by Two Types of Chronic Intermittent Hypoxia in Mice
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Comparison of Clinical Indications Simulating Deficiency of Both Qi and Yin Syndrome Induced by Two Types of Chronic Intermittent Hypoxia in Mice
Chinese Journal of Experimental Traditional Medical FormulaeVol. 17, Issue 17, Pages: 171-176(2011)
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Published:2011
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WANG Wen-ping, CHAI Cheng-zhi, KOU Jun-ping, et al. Comparison of Clinical Indications Simulating Deficiency of Both Qi and Yin Syndrome Induced by Two Types of Chronic Intermittent Hypoxia in Mice[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(17): 171-176.
DOI:
WANG Wen-ping, CHAI Cheng-zhi, KOU Jun-ping, et al. Comparison of Clinical Indications Simulating Deficiency of Both Qi and Yin Syndrome Induced by Two Types of Chronic Intermittent Hypoxia in Mice[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(17): 171-176.DOI:
Comparison of Clinical Indications Simulating Deficiency of Both Qi and Yin Syndrome Induced by Two Types of Chronic Intermittent Hypoxia in Mice
Objective: To establish foundation for constructing a suitable animal model of deficiency of both Qi and Yin syndrome (DQYS) induced by two types of chronic intermittent hypoxia (soda lime and low-pressure oxygen controller) by comparison the whole behavior in mice. Method: The two modes of oxygen scarcity
including oxygen pressure declining continuously from 21% to 7%-8% with the average speed of 0.5%/min-1% per minute in airtight wide-mouthed bottle and oxygen pressure falling abruptly within short period and then keeping in the level of 7%-8%
were adopted respectively to observe the time-course changes in body weight
food intake
locomotive activity and electrocardiogram respectively. The experiments were designed for mimicing clinical features of DQYS. Result: The mice exposed to two different modes of chronic intermittent hypoxia for certain duration showed body weight loss
food intake decline
locomotive activity change of ambulation decrease and rearing increase
heart rate increase and T wave elevation. There was significant correlation between the results of the two groups. Conclusion: Both types of chronic intermittent hypoxia can simulate the major clinical features of DQYS mainly characterized by tiredness
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