Objective: To observe promoting blood circulation by removing blood stasis of Huoxue Sanyu granule. Method: Sixty Wistar rats (n=10/group) were randomly divided into six group

the normal goup

the model group

the Fufang Danshen Tablets group

high Huoxue Sanyu granule group(16 g·kg-1)

middle Huoxue Sanyu granule group(8 g·kg-1) and low Huoxue Sanyu granule group(4 g·kg-1). The trement groups were orally administered once per day for 9 d separately

whereas the normal and model group were orally administered with distilled water.Except norml rats

all the other rats were injected subcutaneously adrenalin 10 μg·kg-1

swam in icy water 5 min after 2 h the acute blood stasis rat models were made

and these rats were injected subcutaneously adrenalin 10 μg·kg-1 again after 2 h.The indexes on hemorheology after given drugs for nine days were measured order to investigate the influences of Huoxue Sanyu granule;mesenteric microcirculatory disturbance rat models were established with adalin in order to observe the effects of this drug. Result: Huoxue Sanyu granule could decrease rats blood viscosity

plasma viscosity

and relieve viscosity and coagulating condition of blood stasis rats blood

so it inhibited thrombosis;it could also inhibit the caliber decreasing of thin artery

the slowing of blood flow

the reducing of open capillaries and chang of fluid condition and improve these phenomena. Conclusion: Huoxue Sanyu granule may improve blood stasis rats hemorheology and microcirculatory disturbance.