Effect of Yanshuai Mixture on Spleen Histopathology and IL-2 in -galactose induced Aging Mice
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Effect of Yanshuai Mixture on Spleen Histopathology and IL-2 in -galactose induced Aging Mice
Chinese Journal of Experimental Traditional Medical FormulaeVol. 17, Issue 16, Pages: 188-191(2011)
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Published:2011
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LUAN Zeng-qiang, CAO Wen-fu, HUANG He-xian. Effect of Yanshuai Mixture on Spleen Histopathology and IL-2 in -galactose induced Aging Mice[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(16): 188-191.
DOI:
LUAN Zeng-qiang, CAO Wen-fu, HUANG He-xian. Effect of Yanshuai Mixture on Spleen Histopathology and IL-2 in -galactose induced Aging Mice[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(16): 188-191.DOI:
Effect of Yanshuai Mixture on Spleen Histopathology and IL-2 in -galactose induced Aging Mice
Objective: To study the effect of Yanshuai mixture (YSM) on the spleen tissue structure and serum interleukin 2 (IL-2) levels in D-galactose induced sub-acute aging mice. Method: The aging mice were established by D-galactose (120 mg·kg-1·d-1) and administered continuously with YSM for 8 weeks. The spleen index and changes in spleen endoscopic biopsy morphology were observed
IL-2 levels in serum were detected using enzyme-linked immunosorbent assay (ELISA). Result: The spleen index of aging model mice was decreased (0.25±0.05)%
histopathological changes in spleen were degraded significantly
and IL-2 level (0.90±0.17)μg·L-1 was significantly reduced compared with those in normal control group (P<0.05). After the treatment with YSM
spleen histomorphological changes were ameliorated
the spleen index of high-dose YSM mice(0.37±0.04) was increased and level of IL-2 in the serum (2.47±0.77)μg·L-1 was increased (P<0.05). High-dose YSM group was superior to Bushen Yishou capsule (BSYS) group
low and middle-dose YSM group (P<0.05). Conclusion: YSM can improve the spleen histopathological changes
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