Pharmacodynamic Study on Cactus Fruit Polysaccharide Extract

LIU Hua-gang; LIANG Qiu-yun; HUANG Hui-xue; CAO Jun-tao; MENG Hua-lin; LIANG Bei-bei

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Pharmacodynamic Study on Cactus Fruit Polysaccharide Extract

更新时间：2024-01-04

- Pharmacodynamic Study on Cactus Fruit Polysaccharide Extract
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 17, Issue 19, Pages: 170-173(2011)
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- Published：2011
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LIU Hua-gang, LIANG Qiu-yun, HUANG Hui-xue, et al. Pharmacodynamic Study on Cactus Fruit Polysaccharide Extract[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(19): 170-173.
DOI：

LIU Hua-gang, LIANG Qiu-yun, HUANG Hui-xue, et al. Pharmacodynamic Study on Cactus Fruit Polysaccharide Extract[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(19): 170-173. DOI：

摘要

目的: 探讨仙人掌果多糖提取物(CPFP)的降血糖、降血脂、降血压及抗肿瘤作用。方法: 以链脲佐菌素(STZ)诱导SD大鼠成糖尿病模型

随机分为模型组、胰岛素组(10 U·kg-1·d-1

sc给药)、CPFP高、低剂量组(2.37

1.58 g·kg-1·d-1)

连续ig 8周

观察各组大鼠血糖的变化;以高脂饲料饲养SD大鼠3周

建立高脂血症模型后

随机分为模型组

洛伐他汀组(3.0 mg·kg-1·d-1)、CPFP高、低剂量组(2.37

1.19 g·kg-1·d-1)

连续ig 3周

观察各组大鼠血脂的变化;15周自发性高血压大鼠(SHR)50 只

随机分为模型组、卡托普利组(0.01 g·kg-1·d-1)、CPFP高、中、低剂量组(2.37 g·kg-1·d-1

1.58

0.76 g·kg-1·d-1)

同龄正常血压的Wistar大鼠10只为正常对照组

连续ig 9周

每周测血压1次

观察各组大鼠血压的变化;建立S180荷瘤小鼠移植瘤模型

随机分为模型组、环磷酰胺组(CTX

0.02 g·kg-1·d-1

ip给药)、CPFP高、中、低剂量组(1.97

0.99

0.49 g·kg-1·d-1)

连续ig 10 d

检测CPFP对荷瘤小鼠的抑瘤率。结果: 与模型组比较

CPFP可明显降低糖尿病大鼠血糖(P<0.05或P<0.01)

CPFP高、低剂量组的降糖率分别为54.08%

44.73%;与模型组比较

CPFP给药组血清总胆固醇(TC)、甘油三脂(TG)和低密度脂蛋白-胆固醇(LDL-C)水平显著降低(P<0.01)

CPFP高剂量组高密度脂蛋白-胆固醇(HDL-C)水平明显升高(P<0.05);9 周后各给药组大鼠的血压较SHR模型组明显降低(P<0.01)

而模型组血压明显高于正常组大鼠(P<0.01);给药10 d 后

CPFP高、中剂量组对肿瘤均有明显的抑制率

抑瘤率分别为49.70%

31.13%。结论: CPFP具有明显降低STZ诱导的糖尿病大鼠血糖、降低高血脂症大鼠血脂、降低SHR血压及抗肿瘤作用。

Abstract

Objective: To explore antihyperglycemic

antihyperlipidemic

antihypertensive and anti-tumor effects of the cactus fruit polysaccharide extract(CPFP). Method: The diabetic rats were induced by STZ in SD rats

and randomly divided into model group

insulin group(10 U·kg-1·d-1)

high-dose group of CPFP(2.37 g·kg-1·d-1)

low-dose group of CPFP(1.58 g·kg-1·d-1). The CPFP were administrated daily via gavage for eight weeks. During the experiment

the blood glucose of rats were determined. Male SD rats were fed by hyper-fatty diet for 3 weeks in order to establish the hyperlipemia rat model. The hyperlipemia rats were randomly divided into model group

lovastatin group(3.0 mg·kg-1·d-1)

high-dose group of CPFP(2.37 g·kg-1·d-1)

low-dose group of CPFP(1.19 g·kg-1·d-1). Different dose of CPFP were administrated daily via gavage for 3 weeks. The blood lipoprotein of rats were determined. Fifty male spontaneous hypertension rats(SHR)at the age of 15 weeks were randomly divided into model group

captopril group(0.01 g·kg-1·d-1)

high-dose group of CPFP(2.37 g·kg-1·d-1)

middle-dose group of CPFP(1.58 g·kg-1·d-1)

low-dose group of CPFP(0.76 g·kg-1·d-1). Ten male Wistar rats were served as normal group. Different dose of CPFP were administrated daily via gavage for 9 weeks. The systolic blood pressure(SBP)of experimental rats was detected weekly. S180-tumor bearing mice were established and divided into model group

cyclophosphamide(CTX)group(0.02 g·kg-1·d-1)

high-dose group of CPFP(1.97 g·kg-1·d-1)

middle-dose group of CPFP(0.99 g·kg-1·d-1)

low-dose group of CPFP(0.49 g·kg-1·d-1). The CPFP were administrated daily via gavage for 10 days. Tumor inhibition rates were recorded. Result: Compare with model group

the content of blood glucose was remarkably decreased and the hypoglycemic rates were 54.08% and 44.73% respectively in high-dose and low-dose group of CPFP. The levels of TC

TG and LDL-C were decreased significantly(P<0.01)in high-dose and low-dose group of CPFP. The level of HDL-C was obviously increased in high dose group of CPFP(P<0.05). The SBP level of SHR in CPFP treatment groups was depressed notability

nevertheless the SBP level of SHR of model group was increased obviously comparing with normal group after 9 weeks. The tumor was inhibited in CPFP treatment groups. The tumor inhibited rates were 49.70%

31.13 in high-dose

middle-dose group of CPFP respectively after 10 days. Conclusion: CPFP could markedly decrease blood glucose in STZ-induced diabetic rats and decrease blood lipoprotein in hyperlipemia rats. CPFP showed effects on reducing blood pressure in SHR and certain anti-tumor.

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