Protective Effect of Dihydroquercetin on Acute Myocardial Ischemia Induced by Isoproterenol in Rats

WANG Qiu-hong; KUANG Hai-xue; WU Lun; LI Yang; WANG Zhi-bin

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Protective Effect of Dihydroquercetin on Acute Myocardial Ischemia Induced by Isoproterenol in Rats

更新时间：2024-01-04

- Protective Effect of Dihydroquercetin on Acute Myocardial Ischemia Induced by Isoproterenol in Rats
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 17, Issue 17, Pages: 177-180(2011)
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- Published：2011
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WANG Qiu-hong, KUANG Hai-xue, WU Lun, et al. Protective Effect of Dihydroquercetin on Acute Myocardial Ischemia Induced by Isoproterenol in Rats[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(17): 177-180.
DOI：

WANG Qiu-hong, KUANG Hai-xue, WU Lun, et al. Protective Effect of Dihydroquercetin on Acute Myocardial Ischemia Induced by Isoproterenol in Rats[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(17): 177-180. DOI：

摘要

目的: 研究二氢槲皮素对异丙肾上腺素致大鼠心肌缺血的保护作用

探讨其对冠心病的防治作用及机制。方法: 将SD大鼠随机分为空白组、模型对照组、阳性对照组(地奥心血康 42 mg·kg-1)、二氢槲皮素高、中、低剂量组(6.4

3.2

1.6 mg·kg-1)。皮下注射5 mg·kg-1异丙肾上腺素(ISO)造成心肌缺血性损伤模型后观察心电图(ECG)的变化

检测血清和心肌组织中超氧化物歧化酶(SOD)、丙二醛(MDA)和血清中肌酸激酶(CK)、肌酸激酶同工酶(CK-MB)和乳酸脱氢酶(LDH)含量变化

并对大鼠心肌组织进行了病理切片检查。结果: 二氢槲皮素能改善大鼠ECG的J点位移

显著降低心肌缺血大鼠血清中CK

CK-MB

LDH的含量

升高心肌组织匀浆中SOD活力

降低心肌组织匀浆中脂质过氧化终产物MDA的含量。结论: 二氢槲皮素能有效抑制ISO所致心肌组织缺血

保护心肌细胞免受损伤

从而起到治疗冠心病的作用。

Abstract

Objective: To study the effects and mechanisms of dihydroquercetin against myocardial ischemic model induced by isoproterenol in rat. Method: The health SD rats were randomly divided into blank group

model group

three dose groups of dihydroquercetin. Myocardial injury model was induced by subcutaneous injection of isoproterenol (5 mg·kg-1). The electrocardiogram ECG was recorded

superoxid dismutase(SOD)

malondialdehyde(MDA)

creatine kinase(CK)

creatine kinase isoenzymes(CK-MB) and lactate dihydrogenase (LDH) in the blood were detected by ELISA

pathological changes of rat’s myocardial tissue were determined by hematoxylin-eosin(HE) stainning. Result: J point displacement in ECG was improved in dihydroquercetin group. Serum CK

CK-MB and lactate dihydrogenase(LDH) decreased significantly in dihydroquercetin group compared with those in the model group. SOD activity increased and MDA content lowered in myocardial tissue homogenate in dihydroquercetin group. Conclusion: Dihydroquercetin had an effective role to treat coronary heart disease by inhibiting myocardial tissue ischemia induced by ISO and protecting myocardial cells from injury.

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