Preparation and Drug Release Behavior in vitro of Medicine Loaded PVA Fibrous Membrane

SUI Chun-hong; WANG Cheng; DONG Shun-fu; LV Shao-wu; HAN Li-qin; ZHANG Xiu-rong

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Preparation and Drug Release Behavior in vitro of Medicine Loaded PVA Fibrous Membrane

更新时间：2024-01-04

- Preparation and Drug Release Behavior in vitro of Medicine Loaded PVA Fibrous Membrane
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 17, Issue 19, Pages: 50-53(2011)
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- Published：2011
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SUI Chun-hong, WANG Cheng, DONG Shun-fu, et al. Preparation and Drug Release Behavior in vitro of Medicine Loaded PVA Fibrous Membrane[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(19): 50-53.
DOI：

SUI Chun-hong, WANG Cheng, DONG Shun-fu, et al. Preparation and Drug Release Behavior in vitro of Medicine Loaded PVA Fibrous Membrane[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(19): 50-53. DOI：

摘要

目的: 对载药聚乙烯醇(PVA)超细纤维膜的制备及体外释药行为进行研究。方法: 利用静电纺丝技术制备了相对质量分数分别为10%

20%

30%

40%的硒化环糊精(2-SeCD)/聚乙烯醇(PVA)超细纤维

通过红外光谱(FT-IR)以及扫描电镜照片(SEM)对不同质量分数的载药纤维进行了结构和性能的表征

紫外-可见光分光度计测试了载药超细纤维在人工肠液

人工胃液的体外释药行为。结果: 随着2-SeCD含量的增加

载药纤维直径变大

累计释药曲线增长趋于缓慢

同一体积分数的载药超细纤维

在人工肠液中的累计释药率高于人工胃液的释药率。结论: 载药超细纤维具有较好的缓释效果

有一定的靶向药位。

Abstract

Objective: To study on preparation and drug release behavior in vitro of medicine loaded polyvinyl alcohol(PVA)fibrous membrane. Method: The micro-fibers of 2-SeCD/PVA were prepared by electrospun technique

whose relative weight percentage was 10%

20%

30% and 40% respectively. The structure and property of medicine loaded micro-fibers with different weight percentage were characterized by FT-IR and SEM. Drug release behavior in vitro of medicine loaded micro-fibers were investigated by ultraviolet-visible spectrometer in artificial intestinal fluid and artificial gastric juice. Result: The diameter of medicine loaded fibers became larger with increasing 2-SeCD content

however

the grown of accumulative released medicine curve was slower.The cumulative drug release percentage was higher in the simulated intestinal fluid than in the gastric juice with the same volumn percentage of 2-SeCD/PVA micro-fibers. Conclusion: Medicine loaded micro-fibers had better effective sustained-release and certain targeted drug delivery.

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Related Institution

College of Pharmaceutical Engineering of Traditional Chinese Medicine （TCM）， Tianjin University of TCM

Tianjin Modern Innovation TCM Technology Co. Ltd.

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