Effects of Total Flavonoids in on Hyperglycemia Rat During Streptozotocin Diabetes

ZHENG Chu; TANG Jin-liang; YANG Dong-ye; TANG Ling

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Effects of Total Flavonoids in on Hyperglycemia Rat During Streptozotocin Diabetes

更新时间：2024-01-04

- Effects of Total Flavonoids in on Hyperglycemia Rat During Streptozotocin Diabetes
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 17, Issue 22, Pages: 194-197(2011)
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- Published：2011
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ZHENG Chu, TANG Jin-liang, YANG Dong-ye, et al. Effects of Total Flavonoids in on Hyperglycemia Rat During Streptozotocin Diabetes[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(22): 194-197.
DOI：

ZHENG Chu, TANG Jin-liang, YANG Dong-ye, et al. Effects of Total Flavonoids in on Hyperglycemia Rat During Streptozotocin Diabetes[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(22): 194-197. DOI：

摘要

目的 :观察罗汉果总黄酮降糖作用及其作用机制。方法 :用链脲佐菌素(STZ)1次性ip 70 mg·kg-1建立大鼠糖尿病模型

72 h后将血糖值≥19 mmol·L-1糖尿病大鼠按血糖值随机分成模型组、罗汉果总黄酮高、中、低剂量组(80

20 mg·kg-1)和二甲双胍组(10 mg·kg-1)

另取正常大鼠作为对照组(n=10)。ig给药

每日1次

连续28 d后测定糖尿病大鼠血糖(Glu)、超氧化物歧化酶(SOD)、丙二醛(MDA)、谷胱甘肽过氧化物酶(GSH-Px)、血脂、胰岛素水平及胰腺病理组织学检查。结果 :罗汉果总黄酮80 mg·kg-1剂量组能使 STZ糖尿病大鼠Glu由(22.68±2.55)mmol·L-1降至(10.63±2.88) mmol·L-1

40 mg·kg-1剂量组能使大鼠的血糖值由(23.23±2.52) mmol·L-1降至(12.34±3.6) mmol·L-1(P<0.05

P<0.01);罗汉果总黄酮80 mg·kg-1剂量组能显著提高血清中SOD

GSH-Px活性和降低 MDA含量(P<0.05);罗汉果总黄酮80 mg·kg-1剂量组对血脂(TC

TG)有显著降低作用(P<0.05);罗汉果总黄酮80 mg·kg-1剂量组显著提高血清中胰岛素水平(P<0.05)。结论 :罗汉果总黄酮对STZ糖尿病大鼠有降糖及降血脂作用。

Abstract

Objective :To investigate the improved hypoglycemic effects of total flavonoids in Momordica grosvenori on experimental diabetes. Method :Streptozotocin (STZ) induced diabetic rats were randomly divided into five group

the model group

the Metformin group

total flavonoids of M.grosvenori (80

20 mg·kg-1) groups and Metformin (8 mg·kg-1)group.The trement groups were orally administered once per day separately

model group were orally administered with distilled water.The blood glucose

SOD

MDA

lipidprofile and in sulin were determined after 28 days. Result : Total flavonoids of M. grosvenori could decreased the leve of blood glucose(P<0.05

P<0.01)

lipidprofile and MDA;increased the activity of SOD(P<0.05)

and restoring the serum insulin level(P<0.05). Conclusion : Total flavonoids of M.grosvenori are potential biological anti-diabetic activity.

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