Effect of Houttuynia Cordata Composition on Renal Lesion in db/db Mice with Diabetes
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Effect of Houttuynia Cordata Composition on Renal Lesion in db/db Mice with Diabetes
Chinese Journal of Experimental Traditional Medical FormulaeVol. 17, Issue 19, Pages: 165-169(2011)
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Published:2011
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BAO Jun-lu, WANG Hai-ying. Effect of Houttuynia Cordata Composition on Renal Lesion in db/db Mice with Diabetes[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(19): 165-169.
DOI:
BAO Jun-lu, WANG Hai-ying. Effect of Houttuynia Cordata Composition on Renal Lesion in db/db Mice with Diabetes[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(19): 165-169.DOI:
Effect of Houttuynia Cordata Composition on Renal Lesion in db/db Mice with Diabetes
Objective: To compare the effects of the ethanol and water extract from houttuynia cordata composition on renal lesion in diabetic db/db mice. And the mechanism of Houttuynia cordata composition on preventing the development of diabetic nephropathy(DN)was also investigated. Method: Twenty-four db/m and db/db mouse with 8 weeks of age were divided into four groups according to their treatment ways:group db/m was treated with distilled water
group db/db with distilled water;gruop db/db with ethanol extracted Houttuynia cordata composition;group db/db with water extracted composition. The changes in body weight
24 h urinary albumin excretion
serum insulin
fasting plasma glucose were measured after mouse were treated for 4 weeks and 8 weeks. Result: After treatment with houttuynia cordata composition for 8 weeks
the plasma glucose
cholesterols and 24 h urinary albumin decreased. Compared with the untreated diabetic controls
both of ethanol and water extracted led to similar amelioration of hyperlipidemia and hyperglycemia
as well as reduction of serum insulin level. Conclusion: The houttuynia cordate composition could improve diabetic nephropathy
and the mechanism might be linked to the reduction of the urinary albumin and improvement of insulin resistance.
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